{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:33:32Z","timestamp":1788431612263,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":129,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014840","name":"Gemeinsame Bundesausschuss","doi-asserted-by":"publisher","award":["01VSF17003"],"award-info":[{"award-number":["01VSF17003"]}],"id":[{"id":"10.13039\/501100014840","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Question and Outcome Measures:<\/jats:bold>\n                    In this study, an intervention group (multimodal therapy for chronic back pain) and a control group (standard outpatient treatment) were compared with regard to the primary endpoint of pain (NRS) at rest and the secondary endpoints pain (NRS) during movement, general health status (Short Form 12 (SF\u201012)), health\u2010related quality of life (EQ\u20105D\u20105L), pain disability index (PDI), Hospital Anxiety and Depression Scale\u2010Germany (HADS\u2010D), and Hannover Functional Ability Questionnaire for Measuring Back Pain\u2010Related Disability (FFbH\u2010R).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design and Participants:<\/jats:bold>\n                    The total patient cohort of this prospective observational multicenter study consisted of 477 patients who were initially enrolled in the study from January 2019 to September 2020.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Intervention:<\/jats:bold>\n                    The intervention group received physiotherapy, pain therapy (pain\u2010therapeutic, body\u2010related, and patient\u2010specific treatment), and control examinations from the responsible physician in a 6\u2010month structured interdisciplinary program. The evaluation points used in the analysis are the baseline survey, 6\u2009months and 12\u2009months after the start of the study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 477 patients (243 in the intervention group and 234 in the control group) were included in the analysis; 42 patients in the intervention group deviated from the eligibility criteria due to insufficient adherence to study participation. Nonetheless, they were included in the analysis in line with the ITT principle. The primary endpoint, pain at rest (NRS), showed greater reductions in the intervention group compared to the control group, with mean differences of \u22120.492 (95% CI: [\u22120.866, \u22120.118],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.010) at 6\u2009months (EVA 3) and \u22120.463 (95% CI: [\u22120.837, \u22120.089],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.015) at 12\u2009months (EVA 5), respectively. Regarding the secondary endpoints, pain during movement exhibited a significantly greater reduction in the intervention group compared to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Quality of life, measured via the EQ\u20105D\u20105L index, improved significantly more in the intervention group than in the control group, as did functional capacity (FFbH\u2010R) and physical health (SF\u201012 KSK) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). In contrast, mental health (SF\u201012 PSK) declined significantly during the intervention (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Disability (PDI) exhibited a significantly greater reduction in the intervention group compared to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), whereas anxiety and depression levels (HADS\u2010D) showed only slight changes in both groups, with anxiety being significant at\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0164 and depression not significant at\n                    <jats:italic>p<\/jats:italic>\n                    = 0.1093. These results underscore the intervention\u2019s effectiveness across multiple health dimensions, particularly pain reduction and quality of life.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Multimodal pain therapy over a 6\u2010month period is an effective intervention to improve the perception of pain at rest and during movement while enhancing the subjective quality of life. These benefits persist beyond the therapy period, underscoring the intervention\u2019s lasting impact.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    German Clinical Trials Register: DRKS00015800\n                  <\/jats:p>","DOI":"10.1155\/prm\/6693678","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T07:03:57Z","timestamp":1746860637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a Multimodal Pain Therapy Concept Including Intensive Physiotherapy on the Perception of Pain and the Quality of Life of Patients With Chronic Back Pain: A Prospective Observational Multicenter Study Named \u201cR\u00fctmuS\u201d"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2821-0695","authenticated-orcid":false,"given":"Katharina","family":"Zaglauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-4705","authenticated-orcid":false,"given":"Andrea","family":"Kunsorg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0172-9263","authenticated-orcid":false,"given":"Vanessa","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1300-9299","authenticated-orcid":false,"given":"Lara","family":"G\u00f6rg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8587-639X","authenticated-orcid":false,"given":"Arndt","family":"Oehlschl\u00e4gel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2607-8996","authenticated-orcid":false,"given":"Ursula","family":"Marschall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9026-3809","authenticated-orcid":false,"given":"Dieter","family":"Welsink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Schuhmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-7712","authenticated-orcid":false,"given":"Maria","family":"Wittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"KNGF Guideline on Low Back Pain and Lumbosacral Radicular Syndrome","author":"Royal Dutch Society for Physical Therapy","year":"2021"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.25646\/7854"},{"key":"e_1_2_11_3_2","unstructured":"Statista Anzahl der Arbeitsunfaehigkeitstage in Deutschland nach Diagnose in den Jahren 2017 bis 2021 2023 Statista."},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30970-9"},{"key":"e_1_2_11_5_2","unstructured":"RadtkeR. Krankheitskosten durch Rueckenschmerzen nach Alter und Geschlecht im Jahr 2020 2024 Statista."},{"key":"e_1_2_11_6_2","volume-title":"Gesundheitsatlas Deutschland Rueckenschmerzen Verbreitung in der Bevoelkerung Deutschlands Ursachen","author":"Wissenschaftliches Institut der Aok","year":"2023"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000902"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-015-0030-4"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00003573"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.847460"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.6101\/AZQ\/000330"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00242-0"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8060871"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-022-01258-6"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6414"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1035"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249099"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200103000-00008"},{"key":"e_1_2_11_19_2","volume-title":"Progressive Relaxation: A Physiological and Clinical Investigation of Muscular States and Their Significance in Psychology and Medical Practice","author":"Jacobson E.","year":"1974"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.08.001"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-017-0310-5"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1026\/0012-1924\/a000194"},{"key":"e_1_2_11_23_2","unstructured":"DillmannU. NilgesP. SaileH. andGerbershagenH. U. PDI-Pain Disability Index-Deutsche Fassung 2011 https:\/\/www.testarchiv.eu\/en\/test\/9003694."},{"key":"e_1_2_11_24_2","volume-title":"Hospital Anxiety and Depression Scale: Deutsche Version; HADS-D; Ein Fragebogen zur Erfassung von Angst und Depressivitaet in der Somatischen Medizin; Testdokumentation und Handanweisung","author":"Snaith P.","year":"1995"},{"key":"e_1_2_11_25_2","article-title":"Hannover Functional Questionnaire in Ambulatory Diagnosis of Functional Disability Caused by Backache","volume":"35","author":"Kohlmann T.","year":"1996","journal-title":"Die Rehabilitation"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-07046-w"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005541"},{"key":"e_1_2_11_28_2","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"2009"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2021.12.001"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928473"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200232040-00004"},{"key":"e_1_2_11_32_2","volume-title":"Noninvasive Treatments for Low Back Pain","author":"Chou R.","year":"2016"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h444"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002291"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12846"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00465-7"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000146"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.03.003"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003550"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2014.02.033"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/6693678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/prm\/6693678","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/6693678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:19:00Z","timestamp":1772957940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/prm\/6693678"}},"subtitle":[],"editor":[{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/prm\/6693678"],"URL":"https:\/\/doi.org\/10.1155\/prm\/6693678","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6693678"}}