{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:30:51Z","timestamp":1781173851533,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aimed to evaluate the analgesic efficacy of oral magnesium supplements, administered as an analgesic adjuvant to ibuprofen, on acute postoperative pain within 72\u2009h following mandibular third molar (MTM) surgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    This triple\u2010blind, placebo\u2010controlled, split\u2010mouth randomized study was conducted among 25 patients (50 MTMs), who intended to remove both MTMs. All patients underwent two surgeries separated by an interval of at least 4\u2009weeks. For each surgery period, patients were randomly assigned with either receiving NSAIDs plus oral magnesium supplement (25 MTMs) or NSAIDs plus placebo (25 MTMs) for three days after surgery. The postoperative pain intensity at rest and movement were primarily evaluated at 24\u2009h, postoperatively. Participants were also asked to record pain intensity at 6, 48, and 72\u2009h, postoperatively, rescue analgesic consumption, time to first rescue analgesic, and magnesium\u2010related adverse events.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The combination of ibuprofen plus oral magnesium supplement significantly decreased pain intensity at rest 24\u2009h, postoperatively, compared to placebo (estimated mean difference \u221215.08; 95%CI \u221229.01 to \u22121.14). However, the pain intensity at rest and movement were similar between groups at other time points. There was no significant difference among groups in terms of rescue analgesic consumption and time to first rescue analgesic. No magnesium\u2010related adverse event was observed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The addition of oral magnesium supplement as an analgesic adjuvant to NSAIDs significantly decreased pain intensity at rest 24\u2009h following MTM surgery. Nevertheless, this result might not provide clinically relevant benefits for pain control following MTM surgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.thaiclinicaltrials.org\/show\/TCTR20221003004\">TCTR20221003004<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1155\/prm\/7157801","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T04:36:25Z","timestamp":1737606985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Oral Magnesium Supplement on Postoperative Pain Following Mandibular Third Molar Surgery: A Split\u2010Mouth Randomized Placebo\u2010Controlled Trial"],"prefix":"10.1155","volume":"2025","author":[{"given":"Sutthipat","family":"Nimkulrat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-6254","authenticated-orcid":false,"given":"Phichayut","family":"Phinyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8122-3657","authenticated-orcid":false,"given":"Warit","family":"Powcharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s144066"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05273-8"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2024.1360298"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05221-w"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030325"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep242"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072104"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11121273"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03335-z"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13186"},{"key":"e_1_2_12_11_2","article-title":"Dental Anxiety and the Regular Dental Visits Among the Chulalongkorn University Student: Academic Year 2011","volume":"62","author":"Prugmahachaikul N.","year":"2012","journal-title":"The Journal of the Dental Association of Thailand"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90835-2"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082184"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2334-8"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573401313666170427162740"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051397"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1991.hed3105298.x"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03102.x"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-007-0808-y"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9487-5"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1604257.x"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.03.078"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04170.x"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200109000-00008"},{"key":"e_1_2_12_26_2","first-page":"953","article-title":"Treatment of Fibromyalgia Syndrome With Super Malic: A Randomized, Double Blind, Placebo Controlled, Crossover Pilot Study","volume":"22","author":"Russell I. 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