{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:54:41Z","timestamp":1791442481960,"version":"4.3.3"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":279,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008641","name":"Chung Shan Medical University","doi-asserted-by":"publisher","award":["CSMU-INT-113-18"],"award-info":[{"award-number":["CSMU-INT-113-18"]}],"id":[{"id":"10.13039\/501100008641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The present exploratory study examined a hydroethanolic extract (HEE) and an ethyl\u2010acetate\u2010derived fraction operationally termed the polyphenolic fraction (PF) of\n                    <jats:italic>Dittrichia viscosa<\/jats:italic>\n                    by combining HPLC\u2010PDA fingerprinting, acute nociception and inflammation models, a 72\u2010h acute oral tolerability screen of HEE, and in silico prioritization. The HPLC\u2010PDA fingerprint of HEE contained 31 peaks. Because the available analytical record did not support validated absolute quantification, platform\u2010exported values are reported only as relative chromatographic abundance. The larger peaks included p\u2010coumaric acid (7.20%), caffeic acid (5.11%), a putative caffeic acid\u2010O\u2010hexoside dimer (4.55%), a putative isorhamnetin\u2010O\u2010hexoside (3.57%), a putative hydroxybenzoic acid hexoside (3.25%), and apigenin (3.23%); six annotations were standard\u2010supported, whereas the remaining assignments were putative. In rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095\/group), every treatment\u2010control comparison in the writhing and formalin models was significant in the summary\u2010statistic Dunnett reanalysis (adjusted\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). PF at 100\u2009mg\/kg produced 59.5% writhing inhibition and mean differences versus vehicle of \u221238.46\u2009s (95% CI \u221240.42 to \u221236.50) and \u221223.00\u2009s (95% CI \u221224.45 to \u221221.55) in the early and late formalin phases, respectively. In the carrageenan model, significant differences occurred mainly at 6\u2009h; PF at 100\u2009mg\/kg differed from vehicle by \u22120.24\u2009cm (95% CI \u22120.34 to \u22120.14; adjusted\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0002). Percentage inhibition values are descriptive. No mortality or overt clinical signs were observed after HEE doses up to 4000\u2009mg\/kg during 72\u2009h, which constitutes preliminary acute tolerability evidence for HEE only. Predicted ADMET outputs and AutoDock Vina scores prioritized candidate ligands but do not establish exposure, safety, target inhibition, or causal contribution to the extract\u2010level effects. These exploratory findings support further preclinical investigation, subject to chemical confirmation, raw\u2010data\u2010based longitudinal statistics, direct target assays, and guideline\u2010compliant safety studies.\n                  <\/jats:p>","DOI":"10.1155\/prm\/7424265","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:42:41Z","timestamp":1791441761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Antinociceptive and Anti\u2010Inflammatory Effects of\n                    <i>Dittrichia viscosa<\/i>\n                    Extracts: HPLC\u2010PDA Fingerprinting, Preliminary Acute Tolerability, ADMET Prediction, and Docking\u2010Based Prioritization"],"prefix":"10.1155","volume":"2026","author":[{"given":"Sara","family":"Tlemcani","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology, Environment, Agri-Food, and Health Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  B.P. 1796 Atlas Fez 30000 Morocco  usmba.ac.ma"},{"name":"Laboratory of Engineering, Electrochemistry, Modeling and Environment Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  B.P. 1796 Atlas Fez 30000 Morocco  usmba.ac.ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama","family":"Khibech","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry and Environment Faculty of Sciences Mohammed First University  BP 717 60000 Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Lahkimi","sequence":"additional","affiliation":[{"name":"Laboratory of Engineering, Electrochemistry, Modeling and Environment Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  B.P. 1796 Atlas Fez 30000 Morocco  usmba.ac.ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9870-1803","authenticated-orcid":false,"given":"Abdessadek","family":"Essadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-7098","authenticated-orcid":false,"given":"Chin-Hung","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medical Applied Chemistry Chung Shan Medical University  402 Taichung Taiwan  csmu.edu.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouar","family":"Hmamou","sequence":"additional","affiliation":[{"name":"Laboratory of Engineering, Electrochemistry, Modeling and Environment Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  B.P. 1796 Atlas Fez 30000 Morocco  usmba.ac.ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine Mounadi","family":"Idrissi","sequence":"additional","affiliation":[{"name":"Laboratory of Engineering, Electrochemistry, Modeling and Environment Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  B.P. 1796 Atlas Fez 30000 Morocco  usmba.ac.ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryem","family":"Aichouch","sequence":"additional","affiliation":[{"name":"Department of Chemistry Laboratory of Engineering, Organometallic and Molecular Materials and Environment Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  Fez Morocco  usmba.ac.ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Elrherabi","sequence":"additional","affiliation":[{"name":"Biological Engineering Laboratory Faculty of Sciences and Techniques Sultan Moulay Slimane University  Beni Mellal Morocco  universitesms.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bouhrim","sequence":"additional","affiliation":[{"name":"Biological Engineering Laboratory Faculty of Sciences and Techniques Sultan Moulay Slimane University  Beni Mellal Morocco  universitesms.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Bekkari","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology, Environment, Agri-Food, and Health Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  B.P. 1796 Atlas Fez 30000 Morocco  usmba.ac.ma"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)00393-7"},{"key":"e_1_2_14_2_2","article-title":"Effectiveness and Safety of Non-Steroidal Anti-Inflammatory Drugs and Opioid Treatment for Knee and Hip Osteoarthritis: Network Meta-Analysis","volume":"375","author":"Da Costa B. 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