{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:30:15Z","timestamp":1777865415915,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":118,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471242"],"award-info":[{"award-number":["82471242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23Y11906500"],"award-info":[{"award-number":["23Y11906500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Indwelling nerve catheters are commonly used for postoperative analgesia following limb fracture surgeries. This multicenter, randomized, single\u2010blind, active\u2010controlled parallel trial aimed to compare the novel\n                      <jats:italic>Tuoren<\/jats:italic>\n                      catheter\u2010over\u2010needle assembly with the\n                      <jats:italic>Contiplex D<\/jats:italic>\n                      catheter\u2010through\u2010needle assembly for postoperative pain management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The trial was conducted at three centers in China. Patients undergoing elective limb fracture surgery were randomly assigned (1:1) to either the\n                      <jats:italic>Tuoren<\/jats:italic>\n                      group or the\n                      <jats:italic>Contiplex D<\/jats:italic>\n                      group for postoperative analgesia. The primary outcome was the noninferiority of the\n                      <jats:italic>Tuoren<\/jats:italic>\n                      assembly compared to that of the\n                      <jats:italic>Contiplex D<\/jats:italic>\n                      assembly in terms of the 24\u2010h postoperative analgesia effectiveness rate. Secondary outcomes were patient and surgeon satisfaction, safety, and the time required for puncture and catheter insertion. The rate of local anesthetic leakage and the incidence of catheter kinking and dislodgement during analgesia were also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between June 2019 and June 2021, 232 patients were randomized. The 24\u2010h postoperative analgesia effectiveness rate was 99.1% in both groups. After adjusting for surgery types and centers, the difference was 0.06% [\u22122.36%, 2.49%] with a 95% CI. The lower boundary was above the noninferiority limit of \u221210%. The insertion time for the\n                      <jats:italic>Tuoren<\/jats:italic>\n                      assembly was significantly shorter compared to that of the\n                      <jats:italic>Contiplex D<\/jats:italic>\n                      assembly. Other outcomes did not show statistical differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The novel\n                      <jats:italic>Tuoren<\/jats:italic>\n                      assembly was noninferior to the\n                      <jats:italic>Contiplex D<\/jats:italic>\n                      catheter\u2010through\u2010needle assembly in terms of analgesic effectiveness and safety.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Registry of Clinical Trials: ChiCTR1900022980\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/7529711","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:29:17Z","timestamp":1777530557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and Safety of a Novel Catheter\u2010Over\u2010Needle Assembly for Postoperative Analgesia in Orthopedic Limb Surgery: A Multicenter, Randomized, Single\u2010Blind, Active\u2010Controlled Noninferiority Trial"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7218-7535","authenticated-orcid":false,"given":"Bin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-6135","authenticated-orcid":false,"given":"Hao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0437-9313","authenticated-orcid":false,"given":"Tao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7812-8879","authenticated-orcid":false,"given":"Shukun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7146-6161","authenticated-orcid":false,"given":"Shuqi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-2268","authenticated-orcid":false,"given":"Zitong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9191-8558","authenticated-orcid":false,"given":"Nu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8798-7553","authenticated-orcid":false,"given":"Hongcheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8388-4010","authenticated-orcid":false,"given":"Xiaodan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0043-2332","authenticated-orcid":false,"given":"Xiyuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0b013e31828866b3"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.08.041"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2018.02.048"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.01.044"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000000688"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu066"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-012-9713-9"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2076-y"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318161528a"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.01151.x"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-021-01554-9"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-013-0032-6"},{"key":"e_1_2_14_13_2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.12659\/MSM.893617","article-title":"Effects of Postoperative Continuous Femoral Nerve Block Analgesia with Braun Continuous Peripheral Nerve Block Catheter Set Versus Novel needle-over-cannula After Total Knee Arthroplasty","volume":"21","author":"Yu B.","year":"2015","journal-title":"Medical Science Monitor"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5007"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197005000-00029"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287642.21534.ed"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2025.0060"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-025-03457-5"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100715600285"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000001581"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200511000-00018"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200803000-00006"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000271912.84440.01"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200307000-00015"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-00115550-200807000-00002"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet198"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.64.5.432"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.104"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516667906"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/7529711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/prm\/7529711","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/7529711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:29:28Z","timestamp":1777530568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/prm\/7529711"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"Vittori","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/prm\/7529711"],"URL":"https:\/\/doi.org\/10.1155\/prm\/7529711","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7529711"}}