{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:08:32Z","timestamp":1793862512110,"version":"4.6.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":190,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    The objective was to compare the effectiveness of a combined pain neuroscience education and resistance training program (PNE\u2009+\u2009RT) with that of a combined aerobic and flexibility exercise program (AE\u2009+\u2009FE).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design:<\/jats:bold>\n                    A randomized pilot study was conducted in women with fibromyalgia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Thirty\u2010one women with fibromyalgia were randomized into the experimental group (PNE\u2009+\u2009RT,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915) and the usual care group (AE\u2009+\u2009FE,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916). Both groups carried out the intervention 3\u2009days a week for 12\u2009weeks. Primary outcomes were pain intensity, disability, and symptoms related to central sensitization (CS). Among them, pain intensity was considered the main primary endpoint for statistical analysis and interpretation. Secondary outcomes were pressure pain threshold (PPT), maximum handgrip strength (MHS), and stiffness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Statistically significant between\u2010group differences were found in favor of PNE\u2009+\u2009RT group for short\u2010term pain intensity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and PPT trapezius (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). PNE\u2009+\u2009RT also showed statistically significant within\u2010group improvements in pain intensity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), CS\u2010related symptoms (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), PPT quadriceps (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), and MHS of the left hand (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). Disability improved significantly in both groups (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). There were no significant changes in stiffness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The PNE\u2009+\u2009RT program is more effective than the AE\u2009+\u2009FE program in improving pain intensity in the short term and PPT in the trapezius muscle in the long term. PNE\u2009+\u2009RT is also effective in improving disability, pain intensity, CS\u2010related symptoms (short and long term), and left MHS and PPT in the quadriceps muscle (long term), although it is not more effective than AE\u2009+\u2009FE. The AE\u2009+\u2009FE program is only effective in improving disability. These findings are preliminary, and larger studies are needed to confirm the results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT04855851\n                  <\/jats:p>","DOI":"10.1155\/prm\/7550108","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T13:04:12Z","timestamp":1752152652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pain Neuroscience Education and Resistance Training in Women With Fibromyalgia: A Randomized Control Pilot Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2719-3282","authenticated-orcid":false,"given":"\u00c1lvaro-Jos\u00e9","family":"Rodr\u00edguez-Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-0725","authenticated-orcid":false,"given":"Manuel","family":"Rebollo-Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-3556","authenticated-orcid":false,"given":"Raquel","family":"Chill\u00f3n-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8687-2321","authenticated-orcid":false,"given":"Melania","family":"Cardellat-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2904-5775","authenticated-orcid":false,"given":"Laura","family":"Blanco-Heras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-3305","authenticated-orcid":false,"given":"Jos\u00e9-Jes\u00fas","family":"Jim\u00e9nez-Rejano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00506-w"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-003-0034-0"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2017.06.008"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S178240"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90198-8"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jabr.12137"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209724"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003786.pub2"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010884"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.20.2192"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-018-0033-9"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2014.08.007"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000002318"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14293"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/PM\/PNAC077"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100594"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.14333"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1699-258X(07)73594-5"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/PAPR.12636"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3515-4"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.2196\/13468"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.2519\/JOSPT.1992.16.5.215"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07480-1"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2019-000726"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.4172\/JND.1000116"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.05.005"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3282f5687a"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012700"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.23736\/s1973-9087.17.04876-6"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV.PSYCH.52.1.59"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPAIN.2007.09.005"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/PTJ\/81.10.1629"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081090"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00421-021-04730-4"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.3.1247"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher"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