{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:06:25Z","timestamp":1790672785339,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":271,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010909","name":"Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300420635"],"award-info":[{"award-number":["252300420635"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pressure pain threshold (PPT) is an objective quantitative sensory measure and intermediate biomarker of pain sensitivity. However, the dynamic perioperative alterations and independent clinical determinants of PPT remain insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective observational study included 67 adult patients undergoing orthopaedic trauma surgery. Bilateral PPT of injured and uninjured sides was measured at preoperative baseline and postoperative days (POD) 1\u20133 using a calibrated electronic algometer. Linear mixed\u2010effects models were applied to analyze PPT temporal trends, bilateral differences, and independent associations, with a significance level set at 0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Continuous bilateral PPT reduction was detected throughout the early postoperative phase. The injured side exhibited significantly lower PPT than the uninjured side on POD 1 (mean difference\u2009=\u2009\u22122.43\u2009N, 95% CI: \u22124.08 to \u22120.77,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), whereas no significant bilateral differences were found preoperatively (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.154), on POD 2 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.583), or on POD 3 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.523). No significant time\u2010by\u2010side interaction effects were identified during follow\u2010up. Multivariate analysis demonstrated that age (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.116,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019) positively correlated with PPT, while female sex (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22124.715,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) and elevated body mass index (BMI) (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.441,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022) independently decreased PPT values. In contrast, no statistically significant association with PPT was observed for injury type, surgical approach, and anesthesia regimen in the adjusted model. Sensitivity analyses adjusting for morphine equivalent dose, numeric rating scale pain scores, and length of stay supported the robustness of the key POD 1 side\u2010to\u2010side contrast.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Orthopaedic trauma patients exhibit progressive early\u2010postoperative PPT reduction, with unilateral pain\u2010sensitivity alterations peaking on POD 1. Subsequent bilateral PPT decline may be compatible with broader postoperative changes in pressure pain sensitivity, but mechanistic sensitization cannot be inferred from PPT alone. Independent associations with perioperative PPT were identified for age, sex, and BMI in the adjusted model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III, prognostic study.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Clinical Trial Registry: ChiCTR2500103937\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/8214001","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:38:52Z","timestamp":1790671132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Dynamic Changes and Independent Associations of Pressure Pain Threshold in Trauma Patients: A Prospective Longitudinal Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8065-0748","authenticated-orcid":false,"given":"Zhijie","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0801-5219","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuzhen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-0607","authenticated-orcid":false,"given":"Hewei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2024.08.007"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/phm.0000000000001603"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.09.011"},{"key":"e_1_2_14_4_2","volume-title":"Physiology, Nociception","author":"Armstrong S. 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