{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:38:55Z","timestamp":1780522735607,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The aim of this systematic review and meta\u2010analysis from randomized controlled trials is to assess opioids with or without low\u2010dose naloxone during the perioperative period at pain intensity and opioids\u2010related adverse events.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We searched of Medline, Embase, International Clinical Trials Registry Platform, and the Cochrane Library up to May 31, 2023. We included randomized controlled trials (RCTs) of low\u2010dose naloxone combined with opioids in adults reporting pain intensity or opioid\u2010related adverse event during the perioperative period.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 18 RCTs with 1784 participants were included. We could not reach a consistent conclusion for pain intensity due to high heterogeneity. High certainty evidence showed that low\u2010dose naloxone combined with opioids reduced the risk of nausea (relative risk (RR): 0.82 and 95% confidence interval (CI): 0.70\u20130.96), cough (RR: 0.52 and 95% CI: 0.30\u20130.90) and postoperative nausea and vomiting (RR: 0.58 and 95% CI: 0.40\u20130.80). Moderate certainty evidence showed that low\u2010dose naloxone combined with opioids did not reduce vomiting, urinary retention, sedation, dizziness, respiratory depression, headache, drowsiness, shivering, skin itch, hypotension, and sweating.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Our findings show that the use of low\u2010dose naloxone in combination with opioids can lower the risk of somnolence and coughing, postoperative nausea, and vomiting.\n                  <\/jats:p>","DOI":"10.1155\/prm\/8380502","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T20:02:26Z","timestamp":1740513746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Opioids With or Without Low\u2010Dose Naloxone During the Perioperative Period: A Systematic Review With Meta\u2010Analysis"],"prefix":"10.1155","volume":"2025","author":[{"given":"Benyu","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-1788","authenticated-orcid":false,"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.910"},{"key":"e_1_2_8_2_2","unstructured":"National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology: Adult Cancer Pain(Version 2.2023)."},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2021-103083"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0912-6"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.5812\/ans.108836"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(01)00425-0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2005.08.008"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1930"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004729"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2021.07.010"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199711000-00011"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2001.41.2.190"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200307000-00024"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.09.011"},{"key":"e_1_2_8_17_2","first-page":"228","article-title":"Combination of Morphine with Low-Dose Naloxone for Intravenous Patient-Controlled Analgesia","volume":"27","author":"Zhao L. Y.","year":"2005","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(08)60156-4"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2010.13.015"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12560"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005074"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex253"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000374"},{"key":"e_1_2_8_24_2","first-page":"2229","article-title":"Postoperative Analgesic Effect of Different Doses of Naloxone Combined with Butorphanol and Psychological Nursing Intervention","volume":"31","author":"Zou H.","year":"2018","journal-title":"Pakistan journal of pharmaceutical sciences"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2021.0672"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1050847"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029584"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMT.S4870"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.11.108"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911686"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147445"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/8380502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/prm\/8380502","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/8380502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:22:52Z","timestamp":1772958172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/prm\/8380502"}},"subtitle":[],"editor":[{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/prm\/8380502"],"URL":"https:\/\/doi.org\/10.1155\/prm\/8380502","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8380502"}}