{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:48:32Z","timestamp":1791787712453,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":283,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Painful diabetic peripheral neuropathy (DPN) is common and often inadequately controlled with pharmacological therapy. This study evaluated a clinician\u2010directed, prescription home\u2010use dual\u2010wavelength low\u2010level laser therapy device for temporary relief of painful DPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, randomized, double\u2010blind, sham\u2010controlled trial conducted at four independent U.S. clinical sites, 64 adults with painful DPN were randomized 1:1 to active treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) or sham treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931). The active device emitted simultaneous 640 red and 405\u2009nm violet coherent laser light. Participants self\u2010administered treatment twice daily for 3\u2009weeks, with each session consisting of 5\u2009min per foot. The primary endpoint was the proportion of participants achieving at least a 30% reduction in visual analog scale (VAS) foot pain score from baseline to Week 3. Secondary outcomes included VAS change, neuropathic pain symptoms, treatment satisfaction, durability through Week 7, adherence, blinding integrity, and safety. Participants were required to maintain a stable analgesic and neuropathic\u2010pain regimen throughout, so the intervention was delivered in addition to existing standard care. The primary endpoint was analyzed in the intent\u2010to\u2010treat population, with single imputation for the four participants who withdrew before receiving a device.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At Week 3, 72.7% of active\u2010treated participants met the primary responder criterion compared with 32.3% of sham\u2010treated participants, a between\u2010group difference of 40.5 percentage points (95% CI 18.1 to 62.9) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0024). Mean VAS reduction was greater with active treatment than sham treatment (\u221233.4 vs \u221220.0 points;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). Improvements were sustained through Week 7, with favorable symptom trends, higher satisfaction, and no serious device\u2010related adverse events. Improvement on the neuropathic pain symptom inventory was greatest for paresthesia\/dysesthesia, paroxysmal pain, and burning pain and was not evident for evoked pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Prescription home\u2010use dual\u2010wavelength laser therapy was well tolerated and produced clinically meaningful short\u2010term reductions in foot pain in adults with painful DPN at four independent clinical sites. Because assessment ended four weeks after treatment completion, the findings support short\u2010term pain relief, and the intervention is best positioned as a complementary, nonpharmacological modality used alongside standard care.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT05291975\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/8710857","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:33:24Z","timestamp":1791786804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Wavelength Laser Therapy for Painful Diabetic Peripheral Neuropathy: A Randomized, Double\u2010Blind, and Sham\u2010Controlled Trial"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0497-4031","authenticated-orcid":false,"given":"Sandra","family":"Franco","sequence":"first","affiliation":[{"name":"Franco &amp; Co\u2013Podiatric Medicine &amp; Surgery  Miramar Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Lara","sequence":"additional","affiliation":[{"name":"Weight Loss &amp; Wellness  Dunedin Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Gair","sequence":"additional","affiliation":[{"name":"Laser Chiropractic  West Covina California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Zang","sequence":"additional","affiliation":[{"name":"Regenerative Foot &amp; Ankle Medicine  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2713-5560","authenticated-orcid":false,"given":"Jaime","family":"Franco","sequence":"additional","affiliation":[{"name":"Franco &amp; Co\u2013Podiatric Medicine &amp; Surgery  Miramar Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3163-3513","authenticated-orcid":false,"given":"Steve","family":"Shanks","sequence":"additional","affiliation":[{"name":"Erchonia Corporation  Fountain Inn South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4047-481X","authenticated-orcid":false,"given":"Travis","family":"Sammons","sequence":"additional","affiliation":[{"name":"Erchonia Corporation  Fountain Inn South Carolina 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