{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:03:22Z","timestamp":1786554202768,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":99,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Toradol, a potent nonsteroidal anti\u2010inflammatory drug, is widely used for perioperative analgesia, especially in orthopedic surgeries. Postmarketing surveillance is crucial due to its extensive clinical application. This study aimed to investigate adverse events (AEs) associated with Toradol using the FDA Adverse Event Reporting System (FAERS), analyze the association strengths of key AEs, and provide clinical references.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>FAERS data from 2004 Q1 to 2017 Q4 were analyzed, including reports where Toradol was the primary suspect drug. Disproportionality analyses were conducted using ROR, PRR, BCPNN, and EBGM algorithms to detect safety signals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Among 377 eligible reports, key AEs included immune system disorders (anaphylactic reaction, ROR\u2009=\u200916.28), renal and urinary disorders (oliguria, ROR\u2009=\u200925.57), and gastrointestinal disorders (erosive duodenitis, ROR\u2009=\u2009231.08). Notably, 29.86% of reports were from consumers, with a lower proportion from healthcare professionals. Most AEs (73.10%) occurred within 7\u2009days of administration; rare but severe events, including deafness and cardiorespiratory arrest, were also identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings, derived from hypothesis\u2010generating signal detection analyses, provide real\u2010world safety data on Toradol, highlighting high\u2010risk AEs and reporting biases. Enhanced vigilance and monitoring, especially in high\u2010risk populations, are imperative. However, these signals require confirmation through prospective, controlled studies to establish causality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/8822463","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:39:01Z","timestamp":1775889541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Indications and Adverse Events of Toradol: Based on FDA Adverse Event Reporting System (FAERS)"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3538-0872","authenticated-orcid":false,"given":"Jiaqi","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7135-3601","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2024.11.004"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16391"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.5435\/jaaos-d-24-00786"},{"key":"e_1_2_14_4_2","article-title":"Perioperative Analgesic Interventions for Reduction of Persistent Postsurgical Pain After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis","volume":"144","author":"Laigaard J.","year":"2024","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125162"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-023-03715-7"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013263.pub2"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000002194"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.02.072"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01913-0"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1391356"},{"key":"e_1_2_14_12_2","doi-asserted-by":"crossref","DOI":"10.1007\/s40264-025-01573-2","article-title":"Strategies and Challenges in Coding Ambiguous Information Using MedDRA: An Exploration Among Norwegian Pharmacovigilance Officers","author":"Garmann T.","year":"2025","journal-title":"Drug Safety"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-00635-w"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2368817"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40290-024-00549-4"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102827"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1490334"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.03.045"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.6210"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00484-6"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.05.035"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/corr.0000000000002307"},{"key":"e_1_2_14_23_2","article-title":"Perioperative Testosterone Supplementation Improves Outcomes of Orthopaedic Surgeries: A Systematic Review of Heterogeneous Studies","volume":"41","author":"Flynn M. 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