{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:48:33Z","timestamp":1782978513347,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018684","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["WKZX2024CX301202"],"award-info":[{"award-number":["WKZX2024CX301202"]}],"id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal blockade strategy for thoracic paravertebral block (TPVB) with liposomal bupivacaine (LB) in dual\u2010microport thoracoscopic lobectomy remains unclear. This study evaluated the analgesic efficacy of single\u2010injection versus dual\u2010injection LB in TPVB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective randomized controlled trial enrolled patients undergoing elective dual\u2010port thoracoscopic surgery from June to September 2025. Participants were randomly assigned to either a single\u2010injection group (Group S) or a dual\u2010injection group (Group D). Under ultrasound guidance, Group S received a single 20\u2009mL (266\u2009mg) injection of LB at the thoracic vertebrae 4\u20105, while Group D received two separate 10\u2009mL (133\u2009mg) injections at the thoracic vertebrae 3\u20104 and 6\u20107. The primary outcome was the area under the curve (AUC) of the numerical rating scale (NRS) scores during movement over 72\u2009h postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 92 patients were included in this study, with 46 patients allocated to each group. The mean AUC (SD) of NRS scores during movement at 72\u2009h postoperatively for Groups S and D was 148.83 (80.18) and 201.52 (111.99) NRS\/h, respectively, with a mean difference of 52.69 (95% CI 12.4 to 93.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). The incidence of chronic pain at 3\u2009months postoperatively was 19.6% in Group S and 21.7% in Group D (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.798). Generalized estimating equation analysis showed that at rest, Group S had lower NRS scores than Group D at 48\u2009h postoperatively (95% CI \u20101.4 to \u22120.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044). During movement, the median NRS scores (IQR) at 24\u2009h for Groups S and D were 3.0 (2.0, 3.0) and 3.0 (2.0, 5.0), respectively, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009; at 48\u2009h, the median NRS scores (IQR) were 2.0 (1.0, 3.0) and 2.5 (2.0, 5.0), respectively, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014. The median block duration (IQR) for Groups S and D was 7.00 (6.00, 8.00) and 11.00 (9.75, 12.00), respectively, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; the median hospital stay (IQR) was 4.00 (3.00, 4.25) and 4.00 (4.00, 5.00), respectively, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single\u2010injection LB in TPVB provides comparable or superior analgesic efficacy while significantly reducing the risk of postoperative complications, making it a preferred analgesic strategy.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Registry of Clinical Trials: ChiCTR2500104841\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/8822825","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:03:52Z","timestamp":1782975832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Liposomal Bupivacaine for Single\u2010Injection Versus Dual\u2010Injection Thoracic Paravertebral Block on Analgesic Effect After Dual\u2010Microport Thoracoscopic Lobectomy: A Prospective Randomized Controlled 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