{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:26:47Z","timestamp":1787293607277,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["2024YQ22"],"award-info":[{"award-number":["2024YQ22"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["2023ZX06C02"],"award-info":[{"award-number":["2023ZX06C02"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071549"],"award-info":[{"award-number":["82071549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic migraine is a prevalent and disabling neurological disorder with substantial impact on patients\u2019 quality of life. Understanding the thematic structure and evolution of chronic migraine research is critical for guiding future studies and clinical practice. This study utilized cluster analysis to map research hotspots, thematic developments, and emerging trends in the global literature on chronic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant publications on chronic migraine from 1917 to 2024 were retrieved from the Web of Science Core Collection. Bibliometric and cluster analyses were performed using VOSviewer, CiteSpace, and R 4.3.3, focusing on keyword co\u2010occurrence, thematic clustering, and citation burst analysis to identify research hotspots and their evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 6366 articles were included. Cluster analysis of high\u2010frequency keywords identified five major research clusters: (1) Pathophysiological mechanisms and molecular targets, (2) epidemiology, comorbidities, and quality of life, (3) clinical trials and therapeutic strategies, (4) diagnosis and classification, and (5) regional and national burden. Thematic evolution analysis revealed a shift from early focus on epidemiology and symptomatology to recent emphasis on gene\u2010related peptides, preventive therapies, and resistance mechanisms. Burst keyword analysis highlighted emerging topics such as \u201ccalcitonin gene\u2010related peptide,\u201d \u201cpreventive treatment,\u201d and \u201ccentral sensitization,\u201d reflecting a growing interest in novel biologics and mechanisms of treatment resistance. The United States led in publication volume and collaboration, with\n                      <jats:italic>Headache<\/jats:italic>\n                      ,\n                      <jats:italic>Cephalalgia<\/jats:italic>\n                      , and\n                      <jats:italic>Neurology<\/jats:italic>\n                      as core journals and Harvard University and the Mayo Clinic as the leading institutions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cluster analysis identified five core research areas in chronic migraine and revealed a shift from epidemiological description to molecular mechanisms and individualized treatment. Future research is likely to focus on integrating pharmacological and non\u2010pharmacological interventions to further optimize patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/9934066","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:16:45Z","timestamp":1787293005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cluster Analysis of Global Research Hotspots and Thematic Evolution in Chronic Migraine: A Bibliometric Study 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