{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:07:51Z","timestamp":1789027671728,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":252,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prostate Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgen\u2010deprivation therapy (ADT) for prostate cancer (PCa) is associated with vasomotor symptoms (VMS; hot flashes and night sweats). However, the impact of VMS has not been well characterized. This systematic literature review analyzed patient\u2010reported outcome (PRO) instruments used to assess the quality of life (QoL) impact of ADT\u2010induced VMS as well as the associated humanistic burden and epidemiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE In\u2010Progress, Embase, Cochrane Database of Systematic Reviews (2011\u20132024), and major oncology and health economics and outcomes research conferences (2023\u20132024) were searched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 52 studies were included. Of 15 PRO instruments identified, the most common were the Hot Flash\u2010Related Daily Interference Scale, the Expanded Prostate Index Composite\u201026, and hot flash daily diaries. No PRO instrument was specifically validated to assess the effect of ADT\u2010induced VMS on QoL in PCa. VMS severity (including subjective burden) was significantly associated with QoL, whereas VMS frequency was not. However, no consensus exists on VMS severity definitions. VMS negatively affected sexual functioning, interpersonal relationships, and\/or work productivity, and the associated anxiety, fatigue, insomnia, and poor sleep quality were found to impair QoL. VMS additionally appeared to mediate ADT\u2019s impact on sleep disturbance. ADT\u2010induced VMS rates ranged from 1.4% to 68.9%, with higher frequencies reported within 3\u20136\u2009months of ADT initiation and when adverse events were actively monitored or participants asked to report\/record VMS events (30.7%\u201368.9%). Lower frequencies were seen when VMS were spontaneously captured or in retrospective analyses without active VMS monitoring\/reporting (1.4%\u201315.8%) and with enzalutamide, apalutamide, and abiraterone as add\u2010on therapy to ADT (13.9%\u201315.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VMS severity in men with PCa is more consistently associated with QoL impact versus VMS frequency. A need for PRO instruments specific to treatment\u2010related VMS in PCa and a lack of consensus on definitions of severity for ADT\u2010induced VMS in PCa were identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/proc\/7791468","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:34:31Z","timestamp":1789025671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of Treatment\u2010Induced Vasomotor Symptoms in Men With Prostate Cancer on Androgen\u2010Deprivation Therapy: A Systematic Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1618-9723","authenticated-orcid":false,"given":"Mayank","family":"Ajmera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-2397","authenticated-orcid":false,"given":"Kai-Jye","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5491-3854","authenticated-orcid":false,"given":"Sydney","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1127-8717","authenticated-orcid":false,"given":"Michele","family":"Helbing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf302"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyaf002"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.101"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.4065\/77.11.1207"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.213416"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2024.42.16_suppl.5006"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31024"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2022.40.16_suppl.5067"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2017.1236"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2021-003098"},{"key":"e_1_2_11_12_2","article-title":"The Effect of Androgen Deprivation Therapy on Insomnia Symptoms, Fatigue, Mood, and Hot Flashes in Men With Non-metastatic Prostate Cancer. 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