{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:31:25Z","timestamp":1787225485278,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prostate Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>mpMRI is now widely used before prostate biopsy and has improved the detection of clinically significant prostate cancer (csPCa). However, the subsequent risk of csPCa among men with both negative mpMRI and negative systematic biopsy (SBx) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the observed medium\u2010term risk of csPCa in biopsy\u2010na\u00efve men with initially negative mpMRI and negative SBx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc longitudinal follow\u2010up subanalysis included biopsy\u2010na\u00efve men from the prospective multicenter MULTIPROS trial who had negative baseline mpMRI (PI\u2010RADS \u2264\u20092) and negative SBx. Of the 582 enrolled men, 169 had negative mpMRI; 138 underwent baseline SBx, of whom 8 had csPCa, and 31 had &lt;\u200912\u2009months of follow\u2010up, leaving 99 men for analysis. Follow\u2010up was PSA\u2010based, with repeat mpMRI and biopsy performed when clinically indicated. Kaplan\u2013Meier analysis estimated csPCa\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a mean follow\u2010up of 61.8\u2009\u00b1\u200922.1\u2009months, four patients were diagnosed with csPCa (4\/99; 4.0%). The mean time from initial negative mpMRI to csPCa diagnosis was 68.3\u2009\u00b1\u200922.4\u2009months. Repeat biopsy was performed in 16 patients. csPCa\u2010free survival was 100% at 24\u2009months and 97.3% at 60\u2009months (95% CI: 93.7%\u2013100%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this selected cohort of biopsy\u2010na\u00efve men with both negative mpMRI and negative SBx, the observed incidence of csPCa during medium\u2010term follow\u2010up was low but based on only four events. Because repeat imaging and biopsy were selectively triggered rather than systematically performed, the true incidence of csPCa may be underestimated. Continued PSA\u2010based monitoring, with repeat mpMRI and biopsy when clinically indicated, remains important.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/proc\/9470087","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:22:12Z","timestamp":1787224932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Observed Risk of Clinically Significant Prostate Cancer After Negative mpMRI and Systematic Biopsy in Biopsy\u2010Na\u00efve Men: A MULTIPROS Subanalysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6829-3310","authenticated-orcid":false,"given":"Wafa D.","family":"Aloufi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-9646","authenticated-orcid":false,"given":"Magdalena","family":"Szewczyk-Bieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Nabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5714-4863","authenticated-orcid":false,"given":"Cheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-9701","authenticated-orcid":false,"given":"Luigi","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049787"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23689"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.06.025"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2540"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.10.048"},{"key":"e_1_2_14_6_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.6004\/jnccn.2023.0014","article-title":"Prostate Cancer Early Detection, Version 1.2023: Featured Updates to the NCCN Guidelines","volume":"21","author":"Moses K. A.","year":"2023","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"e_1_2_14_7_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic Accuracy of Multiparametric MRI and TRUS Biopsy in Prostate Cancer: The PROMIS Study","volume":"389","author":"Ahmed H. 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NICE Guideline NG131 2019 https:\/\/www.nice.org.uk\/guidance\/ng131."},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.03.048"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3746-0"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2377-y"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2015.15099"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15876"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.03.007"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14853"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.02.026"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.70169"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031918"},{"key":"e_1_2_14_30_2","volume-title":"Statpearls","author":"David M. 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