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Since then, the therapeutic landscape of advanced prostate cancer has significantly evolved. Sipuleucel\u2010T is a personalized, autologous immunotherapy that activates the patient\u2019s immune system to target prostatic acid phosphatase (PAP)\u2013expressing tumor cells and has demonstrated survival benefit in patients with nonopioid requiring mCRPC. Subsequent clinical trials and abundant real\u2010world data have provided further evidence of this novel immunotherapy\u2019s clinical benefit for patients with mCRPC, as well as demonstrating the numerous immune and biologic responses that sipuleucel\u2010T induces. These data have also identified patient\u2010specific factors associated with longer survival, including race, baseline disease burden, and treatment\u2010induced immune responses. Despite the addition of multiple life\u2010prolonging therapeutic modalities now available to treat patients with mCRPC, the mechanism of action of sipuleucel\u2010T remains unique for patients with advanced prostate cancer. 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