{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:19:18Z","timestamp":1780924758429,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> Mucosal infections including vulvovaginal candidiasis are a common problem for women\nwith human immunodeficiency virus (HIV) infection. Our objective was to determine which factors\npredict the development of symptomatic disease among HIV\u2010infected women.<\/jats:p><jats:p><jats:italic>Materials and Methods:<\/jats:italic> In a prospective study from 1991 to 1995, 205 HIV\u2010positive women were\nevaluated every 6 months for occurrences of vulvovaginal candidiasis. Included in the study were\nall initially asymptomatic women, whether they were fungal\u2010culture\u2010positive or \u2010negative at baseline.\nExcluded from the study were all women with symptomatic vulvovaginal candidiasis at the\ninitial visit, those who developed trichomonas vaginitis at any visit, and those who used any antifungal\nagents.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> The risk of the development of vulvovaginal candidiasis did not differ between women\nwho were asymptomatically colonized at baseline and those who were fungal\u2010culture\u2010negative.\nHowever, the risk of developing vulvovaginal candidiasis was increased 6.8 times for women with\nCD4 counts less than 200 cells\/mm<jats:sup>3<\/jats:sup> at baseline.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> Fungal culture is not predictive of the development of symptomatic vulvovaginal\ncandidiasis. Women infected with HIV who have CD4 counts below 200 cells\/mm<jats:sup>3<\/jats:sup> should be\nmonitored more carefully for vulvovaginal candidiasis. Infect. Dis. Obstet. Gynecol. 8:176\u2013180,\n2000.<\/jats:p>","DOI":"10.1155\/s1064744900000247","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:06:12Z","timestamp":1173272772000},"page":"176-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Determinants of Incident Vulvovaginal Candidiasis inHuman Immunodeficiency Virus\u2010Positive Women"],"prefix":"10.1155","volume":"8","author":[{"given":"Emma","family":"Shifrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Matityahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Minkoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,3]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2000\/726976.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2000\/726976.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744900000247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:53:52Z","timestamp":1723060432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744900000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/S1064744900000247"],"URL":"https:\/\/doi.org\/10.1155\/s1064744900000247","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"value":"1064-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"1999-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}