{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:11:07Z","timestamp":1762917067563},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> To compare the compliance, side effects and efficacy of amoxicillin and azithromycin for the treatment\nof <jats:italic>Chlamydia trachomatis<\/jats:italic> infection in pregnancy.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> This is a randomized single\u2010blind trial of women diagnosed with <jats:italic>C. trachomatis<\/jats:italic> before 33 weeks\ngestation.Women were randomly assigned either 500 mg amoxicillin orally three times per day for 7 days or a single\ndose of 1 g azithromycin orally. Patientswere interviewed by telephone approximately 3\u20137 days following therapy\nto assess compliance and side effects. Test of cure was performed at a follow\u2010up visit 4\u20136 weeks following completion\nof therapy.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Thirty\u2010nine patients were randomized with 19 receiving amoxicillin and 20 receiving azithromycin. There\nwere no differences in baseline data between the two groups, and there were no statistically significant differences\nin side effects, compliance or efficacy. In the amoxicillin group 84% of women took all pills, while 100% completed\nthe single 1 g dose of azithromycin. Side effects were common in both groups (38% overall), with 40% of the\nazithromycin group reporting moderate to severe gastrointestinal side effects compared to 17% in the amoxicillin\ngroup (<jats:italic>p<\/jats:italic>  = 0.11). Of patients who returned for follow\u2010up test of cure, 3 of 15 (20%) in the amoxicillin group were\npositive compared with 1 of 19 (5%) in the azithromycin group (<jats:italic>p<\/jats:italic>  = 0.3).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> Side effects of therapy for <jats:italic>C. trachomatis<\/jats:italic> in pregnancy are common. Amoxicillin was slightly better\ntolerated than azithromycin. Compliance and cure rates with both regimens was high.<\/jats:p>","DOI":"10.1155\/s1064744901000321","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:08:38Z","timestamp":1173272918000},"page":"197-202","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Randomized Trial of Azithromycin Versus Amoxicillin for theTreatment of <i>Chlamydia trachomatis<\/i> in pregnancy"],"prefix":"10.1155","volume":"9","author":[{"given":"Jennifer","family":"Kacmar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Cheh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Montagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey F.","family":"Peipert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,5]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2001\/873741.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2001\/873741.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744901000321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:49:10Z","timestamp":1723060150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744901000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/S1064744901000321"],"URL":"https:\/\/doi.org\/10.1155\/s1064744901000321","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"type":"print","value":"1064-7449"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2001-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}