{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:46:45Z","timestamp":1787698005721,"version":"build-2784847793"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> The presence of enterobacteria such as <jats:italic>Escherichia coli<\/jats:italic> in the vagina of normal women is not synonymous\nwith infection. However, vaginal <jats:italic>E. coli<\/jats:italic> may also cause symptomatic infections. We examined bacterial\nvirulenceproperties that may promote symptomatic female reproductive tract infections (RTI) and neonatal sepsis.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> <jats:italic>E. coli<\/jats:italic>  isolated as the causative agent from cases of vaginitis (n = 50), tubo\u2010ovarian abscess (n = 45) and\nneonatal sepsis (n = 45) was examined for selected phenotypic and genetic virulence properties. Results were\ncompared with the frequency of the same properties among fecal <jats:italic>E. coli<\/jats:italic> not associated with disease.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> A significantly greater proportion of infection <jats:italic>E. coli<\/jats:italic> exhibited D\u2010mannose resistant hemagglutination\ncompared with fecal <jats:italic>E. coli<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.01). This adherence phenotype was associated with the presence of P fimbriae\n(<jats:italic>pap<\/jats:italic>) genes which were also significantly more prevalent among isolates from all three infection sites (<jats:italic>p<\/jats:italic> &lt; 0.01).\nThe majority of <jats:italic>p<\/jats:italic><jats:italic>a<\/jats:italic><jats:italic>p<\/jats:italic><jats:sup>+<\/jats:sup>\n isolates contained the <jats:italic>papG3<\/jats:italic> allele (Class II) regardless of infection type. Increased frequency\nof Type 1C genes among vaginitis and abscess isolates was also noted. No significant differences in frequency of\nother bacterial adherence genes, fim, sfa, uca (gaf) or dra were observed.\nE. coli associated with vaginitis was significantly more likely to be hemolytic ( HIY\u2009<jats:sup>+<\/jats:sup>)\n than were fecal isolates\n(<jats:italic>p<\/jats:italic> &lt; 0.05). The HIY\u2009<jats:sup>+<\/jats:sup> phenotype was also more prevalent among tubo\u2010ovarian abscess and neonatal sepsis isolates\n(<jats:italic>p<\/jats:italic> &lt; 0.08).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic><jats:italic>E. coli<\/jats:italic> isolated from female RTI and neonatal sepses possess unique properties that may enhance\ntheir virulence. These properties are similar to those associated with other <jats:italic>E. coli<\/jats:italic> extra\u2010intestinal infections,\nindicating that strategies such as vaccination or bacterial interference that may be developed against urinary tract\ninfections (UTI) and other <jats:italic>E. coli<\/jats:italic> extra\u2010intestinal infections may also prevent selected female RTI.<\/jats:p>","DOI":"10.1155\/s1064744901000333","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:08:38Z","timestamp":1173272918000},"page":"203-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Virulence Factors of <i>Escherichia coli<\/i> Isolated From FemaleReproductive Tract Infections and Neonatal Sepsis"],"prefix":"10.1155","volume":"9","author":[{"given":"Susan W.","family":"Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter A.","family":"Hammill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,9,27]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2001\/569695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744901000333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:49:09Z","timestamp":1723060149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744901000333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/S1064744901000333"],"URL":"https:\/\/doi.org\/10.1155\/s1064744901000333","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"value":"1064-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2001-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}