{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:46:05Z","timestamp":1770752765428,"version":"3.50.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Central Hospital of Sk\u00f6vde"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> Bacterial vaginosis (BV) is a known risk factor for postoperative infection following abdominal hysterectomy.\nVaginal bacterial flora scored as intermediate has been shown to have the same risk of postoperative\ninfection as BV.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Women undergoing total abdominal hysterectomy for benign diseases were open\u2010randomized according\nto Zelen to either treatmentwith metronidazole rectally for at least 4 days or no treatment. At the preoperative\ngynecological examination a vaginal smear was collected and Gram stained. Women with BV or intermediate flora\nwere merged to one group called abnormal vaginal flora.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> In total 213 women were randomized to treatment or no treatment. After exclusion of 71 women, 142\nwomen were eligible for analysis. Among the 59 women diagnosed with abnormal vaginal flora there were no\nvaginal cuff infections in the treated arm, comparedwith 27% in the \u2018no treatment\u2019 arm (<jats:italic>p<\/jats:italic> &lt;0.01). Treatment also\nreduced the vaginal cuff infection rate from 9.5 to 2% among the 83 women with lactobacilli flora. However,\nthis difference was not statistically significant. Treatment had no effect on the rate of wound infections.\nIntention\u2010to\u2010treat analysis showed a significant reduction in vaginal cuff infections among women randomized\nto treatment.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic>  Pre\u2010 and postoperative treatment for at least 4 days with metronidazole rectally reduces\nsignificantly vaginal cuff infection among women with abnormal vaginal flora.<\/jats:p>","DOI":"10.1155\/s1064744902000133","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:12:46Z","timestamp":1173273166000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Does Pre\u2010 and Postoperative Metronidazole Treatment LowerVaginal Cuff Infection Rate After Abdominal HysterectomyAmong Women With Bacterial Vaginosis?"],"prefix":"10.1155","volume":"10","author":[{"given":"Per-G\u00f6ran","family":"Larsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,22]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2002\/514724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744902000133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:58:43Z","timestamp":1723057123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744902000133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1155\/S1064744902000133"],"URL":"https:\/\/doi.org\/10.1155\/s1064744902000133","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"value":"1064-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2001-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}