{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:04:28Z","timestamp":1723075468906},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1886,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1886,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> The purpose of this study was to compare the efficacy and side effects of erythromycin,\namoxicillin, and clindamycin in eradicating <jats:italic>Chlamydia trachomatis<\/jats:italic> from the lower genital tract of\npregnant women.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> A total of 174 women at &lt;36 weeks gestation with positive cervical cultures for <jats:italic>C.\ntrachomatis<\/jats:italic> were enrolled. Patients were assigned in a randomized prospective fashion to either\nerythromycin (500 mg q.i.d, for 7 days), amoxicillin (500 mg t.i.d, for 7 days), or clindamycin (600 mg\nt.i.d, for 10 days). Six women elected not to participate and 8 patients were lost to follow\u2010up, leaving\n53 patients in the erythromycin group, 55 patients in the amoxicillin group, and 52 patients in the\nclindamycin group. All sexual partners of the enrolled women were offered doxycycline (100 mg\nb.i.d. for 7 days) and patients were instructed to use barrier contraception until treatment was\ncomplete.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> All 3 medications were effective agents for the treatment of antenatal <jats:italic>C. trachomatis<\/jats:italic>\ninfection with treatment efficacies of 96%, 94%, and 98% for the erythromycin, amoxicillin, and\nclindamycin groups, respectively. When the antibiotic groups were compared, no statistically significant\ndifferences were noted in intolerance. However, the differences in the incidence of gastrointestinal\nsymptoms between erythromycin and amoxicillin and\/or clindamycin were significant\n(P &lt; 0.05).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> These findings suggest that 1) all 3 antibiotic regimens are efficacious, 2) erythromycin\nhas a higher incidence of side effects, and 3) amoxicillin or clindamycin are reasonable alternatives\nfor the treatment of <jats:italic>C. trachomatis<\/jats:italic> in pregnant patients unable to tolerate erythromycin.<\/jats:p>","DOI":"10.1155\/s1064744995000020","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:01:22Z","timestamp":1173272482000},"page":"205-209","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Randomized Prospective Study Comparing Erythromycin, Amoxicillin, and Clindamycin for theTreatment of <i>Chlamydia trachomatis<\/i> in Pregnancy"],"prefix":"10.1155","volume":"2","author":[{"given":"Mark A.","family":"Turrentine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Troyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Gonik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,11,2]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/1995\/765349.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744995000020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:00:55Z","timestamp":1723071655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744995000020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,2]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1155\/S1064744995000020"],"URL":"https:\/\/doi.org\/10.1155\/s1064744995000020","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"type":"print","value":"1064-7449"}],"subject":[],"published":{"date-parts":[[1994,11,2]]},"assertion":[{"value":"1994-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1994-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}