{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:12:32Z","timestamp":1758924752955},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1826,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1826,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> The purpose of this study was to determine if granulocyte colony\u2010stimulating factor\n(G\u2010CSF) is normally present in amniotic fluid and then to determine if amniotic\u2010fluid G\u2010CSF levels\nare affected by labor and intrauterine infection.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Amniotic fluid was collected from 35 patients in 4 groups: no labor, early labor, late labor, and labor plus chorioamnionitis. G\u2010CSF levels were measured by enzyme\u2010linked immunosorbent\nassay (ELISA).<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> The mean amniotic\u2010fluid G\u2010CSF concentrations prior to labor were lower than during labor (0.49 \u00b1 0.25 ng\/ml for prior to labor vs. 1.83 \u00b1 1.0 ng\/ml for labor, <jats:italic>P<\/jats:italic> &lt; 0.001). With chorioamnionitis, the mean levels were elevated compared with normal labor (25.0 \u00b1 4.8 ng\/ml for chorioamnionitis vs. 1.83 \u00b1 1.0 ng\/ml for normal labor, <jats:italic>P<\/jats:italic> &lt; 0.0001). In early and late labor, G\u2010CSF was higher than prior to labor (0.49 \u00b1 0.25 ng\/ml for no labor vs. 1.48 \u00b1 1.0 ng\/ml for early labor, <jats:italic>P<\/jats:italic> &lt; 0.02, vs. 2.2 \u00b1 0.8 ng\/ml for late labor, <jats:italic>P<\/jats:italic> &lt; 0.0005). The mean concentrations in early and late labor were not different.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> G\u2010CSF is present in amniotic fluid and increased with labor. When labor is complicated by chorioamnionitis, G\u2010CSF is significantly elevated.<\/jats:p>","DOI":"10.1155\/s1064744995000482","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:31:25Z","timestamp":1173274285000},"page":"140-144","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Granulocyte Colony\u2010Stimulating Factorin Amniotic Fluid"],"prefix":"10.1155","volume":"3","author":[{"given":"B. Denise","family":"Raynor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Duff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,9,20]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/1995\/876958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/1995\/876958.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744995000482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:18:02Z","timestamp":1723065482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744995000482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1155\/S1064744995000482"],"URL":"https:\/\/doi.org\/10.1155\/s1064744995000482","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"type":"print","value":"1064-7449"}],"subject":[],"published":{"date-parts":[[1995,1]]},"assertion":[{"value":"1995-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}