{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:29:49Z","timestamp":1767169789519,"version":"build-2238731810"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective:<\/jats:italic>\n                    The aim of this study was to prospectively evaluate the efficacy of a therapeutic course\nof intravenous antibiotics followed by oral antibiotics vs. intravenous antibiotics alone to prevent\nrecurrent urinary tract infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods:<\/jats:italic>\n                    Pyelonephritis was documented by strict criteria in 67 pregnant women who were then\ntreated with appropriate intravenous antibiotics until afebrile and asymptomatic for 48 h. Women\nwere then randomized to completion of a 10\u2010day course of oral nitrofurantoin 100 mg qid or no\nfurther antibiotic therapy. Urine cultures (UC) were obtained 2 and 6 weeks after discharge, and\nat delivery. A positive UC or readmission for pyelonephritis was considered endpoints for participation\nin the study. Antibiotic suppression was not used.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results:<\/jats:italic>\n                    Readmission for pyelonephritis prior to the 2\u2010week follow\u2010up visit occurred in 2\/36\n(5.6%) women randomized to the oral therapy group compared to 4\/31 (12.9%) in the no oral\ntreatment group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.29). At the 2\u2010week follow\u2010up visit, 6\/31 (19.4%) women had a positive UC\nin the oral therapy compared to 8\/26 (30.1%) in the no oral treatment group but this difference was\nnot statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.31).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    Completion of 10 days of antibiotic therapy with oral medication does not significantly\nreduce the risk of recurrent pyelonephritis immediately post\u2010parenteral treatment. Women in\nthe no oral treatment group had a non\u2010significant increase in positive UC at the 2\u2010week follow\u2010up\nvisit. The high rates of recurrent urinary tract infection during pregnancy in both groups underscore\nthe need for regular UC and for the possible role of oral antibiotic suppression.\n                  <\/jats:p>","DOI":"10.1155\/s1064744996000567","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T08:01:43Z","timestamp":1173254503000},"page":"294-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Randomized Clinical Trial of Antibiotic Therapy for Antenatal Pyelonephritis"],"prefix":"10.1155","volume":"4","author":[{"given":"Brian C.","family":"Brost","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Stramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Eller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger B.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,1,14]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/1996\/709094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/1996\/709094.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744996000567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:24:04Z","timestamp":1723051444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744996000567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":0,"aliases":["10.1002\/(sici)1098-0997(1996)4:5<294::aid-idog9>3.0.co;2-y"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1155\/S1064744996000567"],"URL":"https:\/\/doi.org\/10.1155\/s1064744996000567","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"value":"1064-7449","type":"print"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1996-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}