{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:45:00Z","timestamp":1762271100730,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Astra Pharma Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>Bacterial heat shock proteins (Hsps) are abundantly produced during the course of most microbial infections and are often targeted by the mammalian immune response. While Hsps have been well characterized for their roles in protein folding and secretion activities, little attention has been given to their participation in pathogenesis. In the case of <jats:italic>Legionella pneumophila<\/jats:italic>, an aquatic intracellular\nparasite of protozoa and cause of Legionnaires\u2032 disease, Hsp60 is uniquely located in the periplasm and on the bacterial surface. Surface\u2010associated Hsp60 promotes attachment and invasion in a HeLa cell model and may alter an early step associated with the fusion of phagosomes with lysosomes. Avirulent strains of <jats:italic>L. pneumophila<\/jats:italic> containing defined mutations in several <jats:italic>dot\/icm<\/jats:italic> genes\nare defective in localizing Hsp60 onto their surface and are reduced approximately 1000\u2010fold in their invasiveness towards HeLa cells. For the ulcer\u2010causing bacterium <jats:italic>Helicobacter pylori<\/jats:italic>, surfaceassociated Hsp60 and Hsp70 mediate attachment to gastric epithelial cells. The increased expression of these Hsps following acid shock correlates with both increased association with and inflammation of the gastric mucosa. A role for Hsps in colonization, mucosal infection and in promoting inflammation is discussed. Infect. Dis. Obstet. Gynecol. 7:58\u201363, 1999.<\/jats:p>","DOI":"10.1155\/s1064744999000125","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T13:04:05Z","timestamp":1173272645000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surface\u2010Associated Heat Shock Proteins of <i>Legionella pneumophila<\/i> and <i>Helicobacter pylori:<\/i> Roles in Pathogenesis and Immunity"],"prefix":"10.1155","volume":"7","author":[{"given":"P. S.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Garduno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,1]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/1999\/926137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1064744999000125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:20:10Z","timestamp":1723108810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1064744999000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1155\/S1064744999000125"],"URL":"https:\/\/doi.org\/10.1155\/s1064744999000125","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"type":"print","value":"1064-7449"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"1999-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}