{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:58:00Z","timestamp":1791331080104,"version":"4.3.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Nucleotide excision repair (NER) is one of several DNA repair\npathways that are universal throughout phylogeny. NER has a broad\nsubstrate specificity and is capable of removing several classes\nof lesions to the DNA, including those that accumulate upon\nexposure to UV radiation. The loss of this activity in\nNER\u2010defective mutants gives rise to characteristic sensitivities\nto UV that, in humans, is manifested as a greatly elevated\nsensitivity to exposure to the sun. Xeroderma pigmentosum (XP),\nCockayne\u2019s syndrome (CS), and trichothiodystrophy (TTD) are\nthree, rare, recessively inherited human diseases that are linked\nto these defects. Interestingly, some of the symptoms in\nafflicted individuals appear to be due to defects in\ntranscription, the result of the dual functionality of several\ncomponents of the NER apparatus as parts of transcription factor\nIIH (TFIIH). Studies with several model systems have revealed\nthat the genetic and biochemical features of NER are\nextraordinarily conserved in eukaryotes. One system that has been\nstudied very closely is the budding yeast <jats:italic>Saccharomyces\ncerevisiae<\/jats:italic>. While many yeast NER mutants display the expected\nincreases in UV sensitivity and defective transcription, other\ninteresting phenotypes have also been observed. Elevated mutation\nand recombination rates, as well as increased frequencies of\ngenome rearrangement by retrotransposon movement and\nrecombination between short genomic sequences have been\ndocumented. The potential relevance of these novel phenotypes to\ndisease in humans is discussed.<\/jats:p>","DOI":"10.1155\/s1110724302201023","type":"journal-article","created":{"date-parts":[[2002,9,29]],"date-time":"2002-09-29T18:36:23Z","timestamp":1033324583000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nucleotide Excision Repair, Genome Stability, and Human Disease: New Insight from Model Systems"],"prefix":"10.1155","volume":"2","author":[{"given":"David J.","family":"Garfinkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Bailis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,10]]},"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2002\/372317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1110724302201023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T06:20:35Z","timestamp":1722320435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1110724302201023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1155\/S1110724302201023"],"URL":"https:\/\/doi.org\/10.1155\/s1110724302201023","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2001-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-01-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}