{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:07:28Z","timestamp":1777334848658,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01 CA83875"],"award-info":[{"award-number":["1R01 CA83875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Cellular processes such as transcription and DNA repair may be\nregulated through diverse mechanisms, including RNA synthesis,\nprotein synthesis, posttranslational modification and protein\ndegradation. The 26<jats:italic>S<\/jats:italic> proteasome, which is responsible for\ndegrading a broad spectrum of proteins, has been shown to\ninteract with several nucleotide excision repair proteins,\nincluding xeroderma pigmentosum B protein (XPB), Rad4, and Rad23.\nRad4 and Rad23 form a complex that binds preferentially to\nUV\u2010damaged DNA. The 26<jats:italic>S<\/jats:italic> proteasome may regulate repair by\ndegrading DNA repair proteins after repair is completed or,\nalternatively, the proteasome may act as a molecular chaperone to\npromote disassembly of the repair complex. In either case, the\ninteraction between the proteasome and nucleotide excision repair\ndepends on proteins like Rad23 that bind ubiquitin\u2010conjugated\nproteins and the proteasome. While the iteration between Rad4 and\nRad23 is well established, it will be interesting to determine\nwhat other proteins are regulated in a Rad23\u2010dependent manner.<\/jats:p>","DOI":"10.1155\/s1110724302205033","type":"journal-article","created":{"date-parts":[[2002,9,29]],"date-time":"2002-09-29T18:36:23Z","timestamp":1033324583000},"page":"94-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Regulation of repair by the 26<i>S<\/i> proteasome"],"prefix":"10.1155","volume":"2","author":[{"given":"K.","family":"Sweder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Madura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,10]]},"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2002\/594094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1110724302205033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T06:20:24Z","timestamp":1722320424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1110724302205033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1155\/S1110724302205033"],"URL":"https:\/\/doi.org\/10.1155\/s1110724302205033","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2002-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}