{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:04:56Z","timestamp":1765177496065},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":4017,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":4017,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>A computerized electrochemical detection system for application\nafter HPLC, provided with a cyclic voltammetric oxidative and\nreductive module, is described for the on\u2010line qualitative determination\nof electroactive antineoplastic agents and metabolites in urine\nsamples, collected from cancer patients, following intravenous\nadministration.<\/jats:p><jats:p>The application of two cyclic voltammetric detection modes\nprovides an insight into both oxidative and reductive electrode\nreactions of compounds, passing the detector and the occurrence of\n(it)reversible chemical and electrochemical processes at the electrode\nsurface. In this way, redox properties of drugs and metabolites\ncharacteristic of their molecular structure, can be established, which\nmay provide information related to their (enzymatic) bioactivation.<\/jats:p><jats:p>In the cyclic voltammetric mode, the system permits automatic\ndetection of a compound in the cell, recording, storage and plotting\nof voltammograms and calculation of the retention times, the\nhalf\u2010wave potentials and the peak potentials of each scan of all\nindividual compounds. For routine use, storage of 68 voltammograms\non\u2010line is sufficient for the analysis of biological samples in\nclinical\u2010pharmacological research. Special attention has been paid\nto automatic, multi\u2010reference\u2010point component detection.<\/jats:p><jats:p>Based on their concentrations in urine, the oxidative cyclic\nvoltammetric mode, using a glassy carbon electrode, permits the\ndetermination of etoposide and teniposide, whereas the reductive\ncyclic voltammetric mode, with a static mercury drop electrode,\npermits the determination of adriamycin and its metabolite\nadriamycinol.<\/jats:p>","DOI":"10.1155\/s1463924689000246","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T08:53:36Z","timestamp":1173344016000},"page":"106-112","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Computerized cyclic voltammetric detectionafter HPLC of the antineoplastic agentsetoposide, teniposide, adriamycin and itsmetabolite adriamycinol in urine samples"],"prefix":"10.1155","volume":"11","author":[{"given":"H. H. J. L.","family":"Ploegmakers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J. M. M.","family":"Toll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"van Oort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,1]]},"container-title":["Journal of Analytical Methods in Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/1989\/850895.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/S1463924689000246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:45:44Z","timestamp":1723063544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/S1463924689000246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1155\/S1463924689000246"],"URL":"https:\/\/doi.org\/10.1155\/s1463924689000246","archive":["Portico"],"relation":{},"ISSN":["2090-8865","2090-8873"],"issn-type":[{"type":"print","value":"2090-8865"},{"type":"electronic","value":"2090-8873"}],"subject":[],"published":{"date-parts":[[1989,1]]},"assertion":[{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}