{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:42:50Z","timestamp":1794314570793,"version":"4.9.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The goal of this study was to examine the existing evidence from randomized controlled trials (RCTs) on the efficacy of cell treatment in alveolar cleft (AC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design:<\/jats:bold>\n                    An electronic search was done for studies published between January 2000 and May 2024 in the PubMed\/MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases. Primary outcomes were the radiographic assessment of bone graft volume, and the secondary outcome of interest was the number of complications after surgery. A random\u2010effects model and fix\u2010effect model were employed to pool effect sizes, and heterogeneity was assessed using\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Four RCTs, comprising 51 patients, were included in the systematic review and meta\u2010analysis. No statistically significant difference in bone volume (MD [mean difference] \u22120.82; 95% CI [\u22123.59, 5.24];\n                    <jats:italic>p<\/jats:italic>\n                    = 0.71) when using cells therapy to repair AC compared to using autologous iliac crest bone graft repair AC. Also, there is no difference in postoperative complications (MD 0.66; 95% CI [0.13, 3.39];\n                    <jats:italic>p<\/jats:italic>\n                    = 0.62) between the two groups. In this meta\u2010analysis, cells therapy on alveolar bone grafting produced results comparable to autologous bone grafting in new bone formation rate and complications.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In conclusion, this systematic review and meta\u2010analysis appear to indicate no disadvantage to utilizing cell therapy in AC reconstruction versus autologous bone grafting in terms of bone volume or complications.\n                  <\/jats:p>","DOI":"10.1155\/sci\/2780065","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:59:30Z","timestamp":1743458370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stem Cell Therapy\u2019s Efficiency in Reconstructing Alveolar Clefts: A System Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2025","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-3489","authenticated-orcid":false,"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2013.02.002"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1597\/14-290"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199607000-00017"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618780981"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-19921001-14"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-2527-6.00083-9"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2005.01594.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12506"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23111"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656231175278"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13049"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0947-x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31816bdf36"},{"key":"e_1_2_9_14_2","first-page":"264","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"151","author":"Moher D.","year":"2009","journal-title":"PLoS Medicine"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.02.003"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007772"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12602-1"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2012.06.002"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6560234"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6234167"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2021.09.003"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.05.049"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_9_24_2","unstructured":"Manager R: Version 5.4 The Cochrane Collaboration The Nordic Cochrane Centre Copenhagen 2020 Denmark."},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6669168"},{"key":"e_1_2_9_26_2","doi-asserted-by":"crossref","unstructured":"GuyattG. 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