{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:50:46Z","timestamp":1788461446436,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":111,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Bone marrow mesenchymal stem cells (BMSCs), with their potential for multidifferentiation and self\u2010replication, are considered effective for repairing damaged tissues. BMSCs can repair and replace damaged tissues by differentiating into effective cells and secreting some cytokines that inhibit inflammation and promote tissue repair. Recent studies suggest that BMSCs\u2019 main role in tissue repair may involve the secretion of exosomes (BMSC\u2010Exos). Basic research has shown that exosomes can have significant effects on orthopedic diseases such as osteoarthritis, muscle tissue injury, and fractures by stimulating regeneration and reducing inflammation. However, the effect of exosomes on tumor necrosis factor (TNF\u2010\u03b1)\u2010induced muscle atrophy remains unclear.<\/jats:p>\n                  <jats:p>Therefore, this study investigated the mechanism underlying the protective effect of BMSC\u2010Exos on TNF\u2010\u03b1\u2010induced C2C12 myotube atrophy. Treatment with TNF\u2010\u03b1 (20\u2009ng\/mL) for 48\u2009h significantly reduced myotube viability and diameter, which were subsequently reversed by treatment with BMSC\u2010Exos. BMSC\u2010Exos treatment suppressed the expression of E3 ubiquitin ligases, including Atrogin\u20111\/muscle atrophy F\u2011box and muscle ring\u2011finger protein\u20111 (MuRF\u20101). Furthermore, it increased the protein expression levels of myoblast determination protein\u20101 (MyoD) in TNF\u2010\u03b1\u2010induced myotubes. BMSC\u2010Exos also decreased the nuclear translocation of nuclear factor\u2010\u03baB (NF\u2010\u03baB) by inhibiting the phosphorylation of \u03baB inhibitors.<\/jats:p>\n                  <jats:p>These findings indicate that BMSC\u2010Exos may protect against TNF\u2010\u03b1\u2010induced myotube atrophy by inhibiting the proinflammatory NF\u2010\u03baB pathway.<\/jats:p>","DOI":"10.1155\/sci\/3606738","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:01:17Z","timestamp":1776877277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exosomes Derived From Mesenchymal Stem Cells Regulating Myotube Cell Atrophy via NF\u2010\u03baB Signaling Pathway"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9786-2566","authenticated-orcid":false,"given":"Yibing","family":"Ke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1382-7607","authenticated-orcid":false,"given":"Yongping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.227S"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4467"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12125"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115664"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky388"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123418"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04253-0"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/270725a0"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.774570"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12253"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.857291"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00453.2002"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28721"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.902001"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2062183"},{"key":"e_1_2_13_16_2","first-page":"408","article-title":"Characteristics, Applications and Prospects of Mesenchymal Stem Cells in Cell Therapy","volume":"148","author":"Guadix J. 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