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Reducing inflammation and restoring the skin barrier are key to its management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the protective and therapeutic effects of secretory substances from induced pluripotent stem cell (iPSC)\u2010derived mesenchymal stem cells (iMSCs) in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protective effects of iMSC secretome pretreatment were evaluated in HaCaT cells by assessing cell viability, AD biomarker expression, and cell migration. Therapeutic efficacy was examined in a 1\u2010chloro\u20102,4\u2010dinitrobenzene (DNCB)\u2010induced AD mouse model through clinical, histological, and immunological assessments. Proteomic analyses were performed to relevant biological processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      iMSC secretome significantly reduced AD\u2010induced cell death and AD biomarker expressions in vitro (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.05), with 200 \u03bcg\/mL iMSC secretome promoting cell migration. In vivo, high dose (20\u2009mg\/mL) iMSC secretome alleviate clinical indicators compared to the vehicle group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.05). Serum immunoglobulin (Ig) E, interleukin (IL)\u20104, IL\u201031, and IL\u20106 levels, along with the expression of AD biomarkers in skin, were significantly decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.05). Proteomic analyses revealed upregulation of genes involved in the regulation of immune responses and the restoration of skin barrier.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>iMSC secretome demonstrates significant anti\u2010inflammatory and regenerative effects, making it a promising therapeutic option for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/sci\/4412511","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:20:06Z","timestamp":1765524006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["iPSC\u2010Derived MSC Secretome as a Protective and Restorative Modality for Atopic 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