{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:29:09Z","timestamp":1789586949657,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272576"],"award-info":[{"award-number":["82272576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To evaluate the efficacy of stromal vascular fraction (SVF) in treating osteoarthritis (OA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    OA is a common degenerative disease, the most important manifestation of which is cartilage destruction and inflammation. The SVF is a mixed group of multiple cells extracted from adipose tissue with a certain ability to promote tissue repair. However, the biological safety and efficacy of human derived SVF in treating OA have not been confirmed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Seventy\u2010six nude rats were used in this experiment. The rat OA model was constructed with anterior cruciate ligament transection (ACLT). After 4 weeks, SVF cells were injected into the joint cavity once. After 12 weeks, the experimental animals were sacrificed and decalcified sections were subjected to hematoxylin and eosin (H&amp;E), safranine O staining, and AP\u2010PAS staining and immunohistochemistry for inflammation markers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    After surgery, the knee joint swells, pain intensifies, and the joint space narrows. The results of H&amp;E, safranine O, and AP\u2010PAS staining showed that the cartilage tissue was damaged in the ACLT\u2010OA group and the treatment of SVF can reduce cartilage degradation. The numbers of ADAMTS\u20105\u2010, MMP\u201013\u2010, and IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010positive cells significantly decreased and type II collagen\u2010positive cells were more frequently detected in the ACLT\u2010OA group compared with that in the control group, the treatment of SVF can reduce inflammation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    SVF cells can be safely used to treat OA and can both effectively reduce the progression of joint inflammation and promote cartilage regeneration.\n                  <\/jats:p>","DOI":"10.1155\/sci\/5356264","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:25:44Z","timestamp":1741742744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stromal Vascular Fraction Therapy to Reduce Inflammation and Improve Cartilage Regeneration in Osteoarthritis Nude Rats"],"prefix":"10.1155","volume":"2025","author":[{"given":"Xuan-Qi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-873X","authenticated-orcid":false,"given":"Minwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-9457","authenticated-orcid":false,"given":"Chun-Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.11.002"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.10.014"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072146"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.03.011"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02823-1"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2010.0738"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2016-0010"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574888x14666190411121528"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/10_2012_146"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519899923"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113517"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194309"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/832396"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4758930"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719861275"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519880468"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1735249"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology11050681"},{"key":"e_1_2_11_22_2","doi-asserted-by":"crossref","unstructured":"YangW. 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