{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:15:47Z","timestamp":1790802947958,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":201,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["A2125"],"award-info":[{"award-number":["A2125"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endometriosis is a chronic, estrogen\u2010dependent inflammatory disorder characterized by the ectopic implantation of endometrial\u2010like tissue. Although retrograde menstruation is highly prevalent, only a subset of women develops the disease. This epidemiologic paradox suggests that intrinsic molecular alterations in the eutopic endometrium may precondition refluxed cells to survive under inflammatory and oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eutopic endometrial transcriptomes from the GSE6364 dataset (21 endometriosis patients and 16 controls) were analyzed across menstrual phases. Differential expression analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and hallmark inflammatory gene set profiling were performed. Protein\u2013protein interaction (PPI) networks and three machine\u2010learning algorithms maximal clique centrality (MCC), random forest (RF), and least absolute shrinkage and selection operator (LASSO) were applied to identify robust feature genes. Immune cell infiltration was estimated using CIBERSORT . Excision repair cross\u2010complementation group 1 (ERCC1) was further evaluated via cross\u2010species evolutionary conservation and in silico structural modeling of high\u2010risk variants. Additionally, an exploratory stemness\u2013related single\u2010sample gene set enrichment analysis (ssGSEA) was conducted, and correlations between the stemness score and the feature genes were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 443 differentially expressed genes (DEGs) were identified, which were significantly enriched in inflammatory cascades, including the NF\u2010\u03baB, Toll\u2010like receptor, and cytokine signaling pathways. Four convergent feature genes ERCC1, SOX3, P75NTR (encoded by NGFR), and FPR1 were prioritized. Immune deconvolution revealed selective immune remodeling in the eutopic endometrium, characterized by elevated activated natural killer (NK) cells and reduced CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, which correlated significantly with the expression of the feature genes. ERCC1 exhibited high evolutionary conservation, and structural modeling of missense variants predicted the disruption of protein function within conserved DNA repair domains. Exploratory stemness analysis revealed no significant overall case\u2013control difference after adjusting for menstrual phase, though the early secretory subset exhibited a marginally higher score in endometriosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight a stress\u2010adaptive transcriptomic state in the eutopic endometrium driven by inflammatory signaling, selective immune remodeling, and altered DNA repair capacity. Specifically, ERCC1 may serve as a critical mechanistic link between inflammatory pressure and impaired genomic maintenance, thereby facilitating cellular persistence and lesion establishment. Furthermore, our data indicate that this four\u2010gene signature primarily reflects a DNA\u2010repair\u2010adaptive program rather than a global bulk\u2010tissue stemness shift.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/sci\/7134066","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:07:30Z","timestamp":1784632050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative Transcriptomic Analysis Identifies a Key Candidate Gene Bridging Inflammation and DNA Repair in Endometriosis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2442-918X","authenticated-orcid":false,"given":"Juan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-0672","authenticated-orcid":false,"given":"Wangshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2784-658X","authenticated-orcid":false,"given":"Jiuxiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7515-4446","authenticated-orcid":false,"given":"Zhongmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810764"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30003-X"},{"key":"e_1_2_11_4_2","first-page":"151","article-title":"Retrograde Menstruation in Healthy Women and in Patients With Endometriosis","volume":"64","author":"Halme J.","year":"1984","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_11_5_2","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","article-title":"Cancer-Associated Mutations in Endometriosis Without Cancer","volume":"376","author":"Anglesio M. 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