{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:34:45Z","timestamp":1786545285649,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":223,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701700"],"award-info":[{"award-number":["2021YFC2701700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701702"],"award-info":[{"award-number":["2021YFC2701702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preclinical evidence supports the potential use of human umbilical cord blood\u2010derived mononuclear cells (hUCB\u2010MNCs) for preterm infants with preterm birth\u2010associated complications (PBAC). Allogeneic hUCB\u2010MNCs could extend this therapeutic option to infants without autologous cord blood available at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This phase I, open\u2010label, single\u2010arm, and single\u2010center study enrolled 10 preterm infants (gestational age [GA] 27.1\u2009\u00b1\u20090.7 weeks) with two or more PBAC. All received a single intravenous infusion of allogeneic, partially or fully human leukocyte antigen (HLA)\u2010mismatched hUCB\u2010MNCs without preconditioning or immunosuppression. The median cell was (3.51\u2009\u00b1\u20090.93)\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \u2009cells\/kg. Safety, adverse events, and clinical outcomes were assessed over a 2\u2010year follow\u2010up period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All infants survived intensive care unit discharge. Four infants were lost to follow\u2010up for parental reasons, with no in\u2010hospital adverse events noted, their long\u2010term outcomes remain unconfirmed. No infusion\u2010related adverse events, acute reactions, or graft\u2010versus\u2010host disease (GVHD) were detected. One case of cerebral palsy was diagnosed during follow\u2010up and was unrelated to cell infusion. Five of the six infants with evaluable long\u2010term data had no respiratory, developmental, or neurological complications. Plasma inflammatory cytokines exhibited exploratory changes after infusion, without confirmed causality. All infants with follow\u2010up data reached age\u2010appropriate growth at 12 and 24 months of corrected age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No major infusion\u2010related adverse events were observed in preterm infants with PBAC receiving allogeneic hUCB\u2010MNC infusion. Six infants completed 2\u2010year follow\u2010up and four were lost to follow\u2010up. Constrained by small sample size and attrition, the results need further verification in larger controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR\u2010OPN\u201015006932, ChiCTR2000035227<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/sci\/9979914","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:39:12Z","timestamp":1786541952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Cellular Therapy for Preterm Complications: Safety Profile of Allogeneic Cord Blood Mononuclear Cells in a Pilot Clinical 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