{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:39:13Z","timestamp":1793569153376,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2024GXNSFAA010354"],"award-info":[{"award-number":["2024GXNSFAA010354"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB25069271"],"award-info":[{"award-number":["AB25069271"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Mounting evidence indicates that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs\u2010exosomes) combine the advantages of hucMSC pluripotency with their nanoscale dimensions, enhancing their clinical potential through prolonged circulation half\u2010life. Despite these promising characteristics, research on their immunological toxicity remains insufficient. This study focuses on the impact of hucMSC\u2010exosomes on the general toxicity and immunopathological indicators. When mice received tail vein injections of 6\u2009\u00d7\u200910\n                    <jats:sup>10<\/jats:sup>\n                    hucMSC\u2010exosomes particles, we observed no significant changes in body weight, feed intake, blood composition, organ indices, or histopathological findings throughout the 14 days observation period. Similarly, blood levels of immunoglobulins, cytokines, and lymphocyte subpopulations remained stable. The hucMSC\u2010exosomes produced no detectable negative effects on immune organs including the thymus, spleen, and bone marrow. These findings indicate that intravenous administration of 6\u2009\u00d7\u200910\n                    <jats:sup>10<\/jats:sup>\n                    particles of hucMSC\u2010exosomes appears relatively safe at the murine level. This assessment of safety and immunological impact following intravenous hucMSC\u2010exosomes infusion offers experimental support for potential clinical applications and future analyses in this field.\n                  <\/jats:p>","DOI":"10.1155\/sci\/9986368","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T07:34:24Z","timestamp":1745652864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunological Safety Evaluation of Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells in Mice"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1662-0179","authenticated-orcid":false,"given":"Cancan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5169-6618","authenticated-orcid":false,"given":"Zhengmian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-585X","authenticated-orcid":false,"given":"Liang-cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-4955","authenticated-orcid":false,"given":"Zhongquan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5304279"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3500"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03125-1"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.80430"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt213"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.07.018"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21945"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.18.17638"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-063412"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02609-x"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.949724"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03174-7"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070727"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.08.053"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2641-5"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116733"},{"key":"e_1_2_12_18_2","first-page":"101","article-title":"HucMSC Exosomes-Delivered 14-3-3\u03b6 Enhanced Autophagy via Modulation of ATG16L in Preventing Cisplatin-Induced Acute Kidney Injury","volume":"10","author":"Jia H.","year":"2018","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4097-3"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6079642"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01189-x"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2015.11.018"},{"key":"e_1_2_12_23_2","first-page":"127","article-title":"The Role of Immunotherapy in Urologic Cancers","volume":"117","author":"May A.","year":"2020","journal-title":"Missouri Medicine"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S454438"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0529-4"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1869866"},{"key":"e_1_2_12_27_2","first-page":"67","volume-title":"Molecular Therapy. 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