{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:05:23Z","timestamp":1790867123362,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    This study explores the anticancer and antioxidant potential of\n                    <jats:italic>Heliotropium indicum<\/jats:italic>\n                    L. through integrated phytochemical, biological, and computational approaches. GC\u2013MS analysis identified phenol, 3,5\u2010bis(1,1\u2010dimethylethyl) as a major constituent. The chloroform fraction (CHF) exhibited significant\n                    <jats:italic>in vivo<\/jats:italic>\n                    antitumor activity in an Ehrlich ascites carcinoma (EAC) model, showing 76.39% tumor growth inhibition, comparable to bleomycin (80.36%). CHF also demonstrated potent cytotoxicity (LC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200928.96\u2009\u03bcg\/mL) in a brine shrimp assay and protected against AAPH\u2010induced oxidative DNA damage. Molecular docking revealed strong binding of key compounds to topoisomerase II, supported by stable molecular dynamics simulations and favorable MM\u2013PBSA binding energies. These findings highlight\n                    <jats:italic>H. indicum<\/jats:italic>\n                    as a promising source of anticancer and antioxidant agents, warranting further mechanistic and preclinical investigation.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/1079290","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:12:09Z","timestamp":1770235929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Profiling and Computational Docking Studies Revealing the Potential Anticancer and Antioxidant Properties of\n                    <i>Heliotropium indicum<\/i>\n                    L."],"prefix":"10.1155","volume":"2026","author":[{"given":"Sadia Afroz","family":"Shoily","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-8118","authenticated-orcid":false,"given":"Mst. 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Ekramul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190215121712"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1831"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520620666200811122137"},{"key":"e_1_2_15_4_2","first-page":"462","article-title":"A Review on the Pharmacological Potential of the Genus Heliotropium (Boraginaceae)","volume":"7","author":"Gopinathan M.","year":"2020","journal-title":"European Journal of Pharmaceutical and Medical Research"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138962"},{"key":"e_1_2_15_6_2","unstructured":"IslamM. E. ShoilyS. A. ParvinS.et al. 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