{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:40:46Z","timestamp":1773178846392,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":343,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004944","name":"Naresuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    This study aimed to evaluate the efficacy of Thai plant extracts (PEs) and essential oils (EOs) against reference and clinical isolate strains of\n                    <jats:italic>Candida albicans,<\/jats:italic>\n                    focusing on their ability to inhibit biofilm formation, cell adhesion to denture acrylic, and germ tube formation. The minimum biofilm inhibition concentration (MBIC) and the minimum biofilm eradication concentration (MBEC) were determined. The impact on adhesion to denture acrylic was determined by XTT assay, and germ tube inhibition was evaluated using the counting chamber. The results revealed that cinnamon bark oil exhibited the lowest MBIC\n                    <jats:sub>90<\/jats:sub>\n                    and MBEC\n                    <jats:sub>90<\/jats:sub>\n                    values (0.156\u2009mg\/mL and 0.313\u2009mg\/mL, respectively) against both\n                    <jats:italic>C. albicans<\/jats:italic>\n                    strains, followed by lemongrass oil, clove bud oil,\n                    <jats:italic>Alpinia galanga<\/jats:italic>\n                    extract, and\n                    <jats:italic>Piper betle<\/jats:italic>\n                    extract. A similar inhibitory trend was observed for cell adhesion to denture acrylic and germ tube formation. In particular,\n                    <jats:italic>A. galanga<\/jats:italic>\n                    extract (2.50\u2009mg\/mL) significantly reduced\n                    <jats:italic>C. albicans<\/jats:italic>\n                    adhesion to denture acrylic by over 80%. Additionally, cinnamon bark oil, lemongrass oil, and\n                    <jats:italic>A. galanga<\/jats:italic>\n                    extract could inhibit the germination of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    at 0.5\u00d7MIC. In conclusion, this study indicates that all tested agents possessed anti\u2013\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilm activity through decreasing adhesion and yeast\u2013hyphae transition of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cells. Therefore, these EO and PE could serve as alternative antifungals for treating oral candidiasis.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/1766872","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:15:56Z","timestamp":1765412156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multitarget Anti\u2010\n                    <i>Candida<\/i>\n                    Activity of Thai Plant Extracts and Essential Oils: Inhibiting Biofilm Formation, Denture Adhesion, and Germ Tube Formation"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7468-8508","authenticated-orcid":false,"given":"Premnapa","family":"Sisopa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-3433","authenticated-orcid":false,"given":"Supaporn","family":"Lamlertthon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-6412","authenticated-orcid":false,"given":"Ruchadaporn","family":"Kaomongkolgit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-1086","authenticated-orcid":false,"given":"Pratthana","family":"Chomchalao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-0465","authenticated-orcid":false,"given":"Waree","family":"Tiyaboonchai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2020.12.018"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.13687"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1947-y"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2016.43.6.529"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.10.006"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043029"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ebd.6400915"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22978"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.06082-11"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2013.820825"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i9.16"},{"key":"e_1_2_11_12_2","first-page":"144","article-title":"The Antifungal Efficacy of Essential Oils in Combination with Chlorhexidine Against Candida spp","volume":"41","author":"Satthanakul P.","year":"2019","journal-title":"Songklanakarin Journal of Science and Technology"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.21608\/bfsa.2023.207806.1735"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.55164\/ajstr.v28i4.257980"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.06.006"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-016-0256-3"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601509010388"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2012.06.003"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.183.18.5385-5394.2001"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112218"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03183-22"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104690"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-7527-3"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.4047\/jap.2017.9.5.402"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/505204"},{"key":"e_1_2_11_26_2","first-page":"150","article-title":"Antifungal Activity of Cinnamaldehyde Against Candida albicans","volume":"48","author":"Pootong A.","year":"2017","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2012.749398"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.4038\/cjs.v47i2.7511"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1980-65232011000200008"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-007-0097-2"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2005.06.015"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0190-2016"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(12)60026-0"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-849X.2012.00906.x"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.04.002"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.7897\/2230-8407.0911266"},{"key":"e_1_2_11_37_2","unstructured":"HelmiV. N. WidjiastutiR. A. K. A. I. AnisIrmawatiB. andEffendiM. H. TOXICITY TESTING OF CINNAMON BARK (Cinnamomum Burmannii Cortex) ESSENTIAL OIL AS A MOUTHWASH ON FIBROBLAST CELL CULTURE."},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00071"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252010869"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17050546"}],"container-title":["Scientifica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/sci5\/1766872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/sci5\/1766872","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/sci5\/1766872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:04:41Z","timestamp":1772967881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/sci5\/1766872"}},"subtitle":[],"editor":[{"given":"Simone","family":"Carradori","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/sci5\/1766872"],"URL":"https:\/\/doi.org\/10.1155\/sci5\/1766872","archive":["Portico"],"relation":{},"ISSN":["2090-908X","2090-908X"],"issn-type":[{"value":"2090-908X","type":"print"},{"value":"2090-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1766872"}}