{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:17:48Z","timestamp":1780046268371,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":148,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010034","name":"Walailak University","doi-asserted-by":"publisher","award":["HP013\/2021"],"award-info":[{"award-number":["HP013\/2021"]}],"id":[{"id":"10.13039\/501100010034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Derris scandens<\/jats:italic>\n                    (Roxb.) Benth. (Fabaceae) is a medicinal plant with anti\u2010inflammatory properties. Its stem extract is approved in Thailand for treating musculoskeletal pain. However, sustainability concerns necessitate exploring alternative sources such as leaves. This study aimed to compare the phytochemical profiles and anti\u2010inflammatory activity of\n                    <jats:italic>D. scandens<\/jats:italic>\n                    leaves and stems collected from different geographical locations. High\u2010performance liquid chromatography with diode\u2010array detection (HPLC\u2013DAD) was employed to quantify isoflavones in extracts prepared using various ethanol concentrations. Anti\u2010inflammatory activity was assessed through nitric oxide (NO) secretion inhibition in lipopolysaccharide (LPS)\u2010induced RAW 264.7 macrophage cells. Geographical location influenced metabolite profiles and biological activity. Leaves contained isoangustone A (up to 26.6\u2009\u03bcg\/mg) and lupalbigenin (up to 0.98\u2009\u03bcg\/mg), while stems exhibited higher lupalbigenin levels (up to 296\u2009\u03bcg\/mg) and additional metabolites, including derrisisoflavone A and 6,8\u2010diprenylgenistein. At 25\u2009\u03bcg\/mL, NO inhibition by derrisisoflavone A (34.3%) and 6,8\u2010diprenylgenistein (23.3%) was higher than that of leaf\u2010derived compounds such as derrubone (31.0%) and isoangustone A (18.0%). Ethanolic extracts (50\u2009\u03bcg\/mL) of the stems demonstrated greater NO inhibition (9.44%\u201359.6%) compared to the leaves (6.59%\u201339.2%). While\n                    <jats:italic>D. scandens<\/jats:italic>\n                    leaves offer an alternative phytochemical resource, their distinct chemical and biological profiles limit their substitution for the stems as a source of anti\u2010inflammatory metabolites. The findings support the regulatory approval of the stems as an essential Thai medicine. Molecular docking revealed that lupalbigenin showed the strongest binding to COX\u20101, COX\u20102, and 5\u2010LOX, supporting its potential as a dual COX\/LOX inhibitor for anti\u2010inflammatory drug development.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/2028051","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:41:57Z","timestamp":1780044117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical and Geographical Comparison of\n                    <i>Derris scandens<\/i>\n                    (Roxb.) Benth. Leaves and Stems and Their Nitric Oxide Production Inhibitory Activity"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0342-7392","authenticated-orcid":false,"given":"Benyatip","family":"Buajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1840","authenticated-orcid":false,"given":"Mudtorlep","family":"Nisoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-2266","authenticated-orcid":false,"given":"Fonthip","family":"Makkliang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8108-2168","authenticated-orcid":false,"given":"Atthaphon","family":"Konyanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4010-0690","authenticated-orcid":false,"given":"Waraporn","family":"Putalun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-3097","authenticated-orcid":false,"given":"Geoffrey 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