{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:35:02Z","timestamp":1772987702869,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006574","name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur, de la Recherche Scientifique et de la Formation des Cadres","doi-asserted-by":"publisher","award":["Cov\/2020\/07"],"award-info":[{"award-number":["Cov\/2020\/07"]}],"id":[{"id":"10.13039\/501100006574","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Coronavirus disease 2019 (COVID\u201019) has emerged as a global human health threat. While SARS\u2010CoV\u20102 infection exhibits fever and respiratory symptoms, extrarespiratory manifestations were also reported in many cases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    This study aimed to determine the prevalence of digestive and hepatic symptoms at the onset of infection and to assess whether digestive symptoms are associated with severe disease progression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and Methods:<\/jats:bold>\n                    Prospective study was conducted during the first COVID\u201019 wave (from April to October 2020). It included consenting Moroccan patients diagnosed with COVID\u201019 based on PCR test and chest computed tomography.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 211 patients participated in the study. The patients mean age was 42.3\u2009years, with a sex ratio (F\/M) of 1.7. Digestive symptoms were present in 28% of cases, with the most common being nausea or vomiting (12.8%), diarrhea (11.4%), abdominal pain (5.2%), and anorexia (16.6%). These symptoms were significantly associated with diabetes and hypertension. Patients with digestive symptoms reported a significantly higher frequency of anosmia and headache. Hepatic manifestations were present in 21.3%, and digestive symptoms were significantly associated with higher prevalence of liver function disturbances, particularly cholestasis. Nearly half of the patients with digestive symptoms (49.2%) experienced moderate COVID\u201019, with a higher percentage observed (61.8%) among those aged 42\u2009years or older. However, this association was not statistically significant.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Healthcare professionals need to recognize the range of gastrointestinal and hepatic symptoms to ensure timely diagnosis and effective patient management.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/3524776","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:10:55Z","timestamp":1741731055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extrarespiratory, Digestive, and Hepatic Manifestations of COVID\u201019 in a Moroccan 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