{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:34:20Z","timestamp":1772987660212,"version":"3.50.1"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":351,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"publisher","award":["405\/B\/UN3.AGE\/HK.07.01\/2025"],"award-info":[{"award-number":["405\/B\/UN3.AGE\/HK.07.01\/2025"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The study determined the cytotoxicity and teratogenicity of 28 species of medicinal plants. The phytochemical properties and antioxidant activity were also evaluated. Plant materials were extracted using ethanol as solvent. Brine shrimp assay was performed for cytotoxicity test and zebra fish embryo\u2010based teratogenicity testing. The phytochemical constituents were detected using thin\u2010layer chromatography, while the total phenolics and antioxidant activity were determined using the Folin\u2013Ciocalteu method and DPPH free radical scavenging assay, respectively. Results of phytochemical screening revealed the presence of 12 phytochemicals in the selected medicinal plants, which include essential oils, triterpenes, phenols, fatty acids, sugar, anthraquinones, coumarins, anthrone, tannins, flavonoids, steroids, and alkaloids. Total phenolic content which ranges from 125.45 to 568.99 GAE\/g and antioxidant activity of 40.25%\u201382.56% were recorded from\n                    <jats:italic>M. calabura<\/jats:italic>\n                    and\n                    <jats:italic>Z. americana<\/jats:italic>\n                    , respectively. For the cytotoxicity test,\n                    <jats:italic>M. paniculata<\/jats:italic>\n                    registered the least LC\n                    <jats:sub>50<\/jats:sub>\n                    of 1157.42\u2009ppm, while\n                    <jats:italic>C. asiatica<\/jats:italic>\n                    has the highest LC\n                    <jats:sub>50<\/jats:sub>\n                    at 33,252.69\u2009ppm. Meanwhile, for the teratogenicity testing, various morphological abnormalities and teratogenic effects were observed in different developmental stages of zebrafish, which are lethal and sublethal, such as coagulation, yolk sac, and pericardial edema, and malformations (head, spines, and tail), growth retardation, restricted movement, and pigmentation. The LC\n                    <jats:sub>50<\/jats:sub>\n                    values for teratogenicity suggest low to nonteratogenicity of the plant extracts with values ranging from 324\u2009ppm in\n                    <jats:italic>A. brasiliana<\/jats:italic>\n                    to 11,933\u2009ppm in\n                    <jats:italic>P. cablin<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/sci5\/5233425","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:38:16Z","timestamp":1766122696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolites Evaluation, Cytotoxicity, and Teratogenicity Analysis of Selected Medicinal Plants"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-5478","authenticated-orcid":false,"given":"Mary Jhane G.","family":"Valentino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2049-7774","authenticated-orcid":false,"given":"Tutik Sri","family":"Wahyuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"1","article-title":"Target Screening of Plant Secondary Metabolites in River Waters by LC\u2013HRMS","volume":"32","author":"Meyer J.","year":"2020","journal-title":"Environmental Sciences Europe"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2307\/3434847"},{"key":"e_1_2_9_3_2","first-page":"367","article-title":"Natural Products: A Continuing Source of Novel Drug Leads","volume":"1740","author":"Cragg G. 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