{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:52:08Z","timestamp":1777863128239,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":118,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Plant\u2010derived bioactive compounds are recognized as sustainable and promising alternatives to synthetic pharmaceuticals. This study examines the pharmacological efficacy of the methanolic leaf extract of\n                    <jats:italic>Santolina chamaecyparissus<\/jats:italic>\n                    , focusing on its antimicrobial, antioxidant, and anticancer properties. The extract was evaluated by well\u2010diffusion and broth microdilution against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa,<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli,<\/jats:italic>\n                    as well as\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . MICs ranged from 64\u2009\u03bcg\/mL (\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ) to 256\u2009\u03bcg\/mL (\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    ), with 128\u2009\u03bcg\/mL for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>E. coli<\/jats:italic>\n                    , and\n                    <jats:italic>P. aeruginosa.<\/jats:italic>\n                    The antioxidant potential was assessed using a DPPH radical scavenging assay, which revealed a dose\u2010dependent response with 59.23% inhibition at 100\u2009\u03bcg\/mL. Furthermore, the extract displayed potent cytotoxicity against A549\u2009cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 85.38\u2009\u03bcg\/mL at 24\u2009h and 72.46\u2009\u03bcg\/mL at 48\u2009h, indicating its potential as an anticancer agent. Gas chromatography\u2013mass spectrometry analysis identified key phytoconstituents potentially responsible for these bioactivities. These findings highlight the extract\u2019s broad therapeutic promise, supporting\n                    <jats:italic>S. chamaecyparissus as<\/jats:italic>\n                    a candidate for further development in antimicrobial, antioxidant, and anticancer applications.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/7511508","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:21:04Z","timestamp":1777526464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential and Phytochemical Composition of\n                    <i>Santolina chamaecyparissus<\/i>\n                    From Kashmir Himalayas"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-5457","authenticated-orcid":false,"given":"Mohmmad Ashaq","family":"Sofi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5643-333X","authenticated-orcid":false,"given":"Mohd Abass","family":"Sofi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7937","authenticated-orcid":false,"given":"Anima","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3737-6752","authenticated-orcid":false,"given":"Aushiq Amin","family":"Ganaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0002-3890","authenticated-orcid":false,"given":"B. 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