{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:36:20Z","timestamp":1772987780293,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":332,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Antidepressant\u2010like effects of the crude extract of\n                      <jats:italic>Mallotus oppositifolius<\/jats:italic>\n                      (MOE) have been previously demonstrated. However, to overcome the limitations of crude extracts as medicines, we produced an immediate\u2010release formulation of MOE (MOE\u2010IR) and tested its efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the wet granulation method, MOE was formulated into immediate\u2010release dosage forms (MOE\u2010IR F\n                      <jats:sub>1<\/jats:sub>\n                      and F\n                      <jats:sub>2<\/jats:sub>\n                      , 10, 30, 100\u2009mg) and flow properties were assessed with bulk density, tapped density, Carr\u2019s index, Hausner\u2019s ratio, and the angle of repose.\n                      <jats:italic>In vitro<\/jats:italic>\n                      dissolution and antioxidant studies were conducted. Murine unpredictable chronic mild stress and sucrose preference tests (UCMS\u2010SPTs) assessed the antidepressant\u2010like effect. Except for the vehicle nonstressed (VEH\u2010NS) group, mice were subjected to the UCMS for 7\u2009weeks while receiving normal saline (VEH\u2010S, 10\u2009mL\/kg; p.o.), MOE\u2010IR (10, 30, and 100\u2009mg\/kg; p.o.), or fluoxetine (FLX 20\u2009mg\/kg; p.o.) daily for 5\u2009weeks. The weight of mice and sucrose consumption (test for anhedonia) were monitored, after which forced swim test (FST), tail suspension test (TST), and open field test (OFT) were conducted following treatment termination. Plasma corticosterone concentration was assessed using ELISA, and brains were harvested for Golgi\u2010Cox staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MOE\u2010IR F\n                      <jats:sub>1<\/jats:sub>\n                      (10\u2009mg) exhibited the most suitable formulation properties, and the highest release profile in all media, hence, was selected for the proof\u2010of\u2010concept antidepressant study and referred to as MOE\u2010IR. MOE\u2010IR and crude extract demonstrated\n                      <jats:italic>in vitro<\/jats:italic>\n                      antioxidant activity in the DPPH test. MOE\u2010IR just as FLX reversed the stress\u2010induced weight loss, anhedonia as well as decreased immobility time in the FST and TST without affecting locomotor activity. MOE\u2010IR decreased the plasma corticosterone concentration and increased the dentate gyrus (DG) dendritic spine density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, MOE\u2010IR demonstrated antidepressant\u2010like that may be associated with antioxidant effects, decreased plasma corticosterone levels, and increased DG dendritic spine density.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/sci5\/7695732","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T20:08:37Z","timestamp":1764446917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antidepressant\u2010Like Effect of an Immediate\u2010Release Formulation of\n                    <i>Mallotus oppositifolius<\/i>\n                    in Mice"],"prefix":"10.1155","volume":"2025","author":[{"given":"Zakaria Abdullah","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-2042","authenticated-orcid":false,"given":"Ofosua","family":"Adi-Dako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Kofi","family":"Adutwum-Ofosu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-6870","authenticated-orcid":false,"given":"Patrick","family":"Amoateng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frimpong","family":"Appiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awo Efua","family":"Koomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatus Wewura","family":"Adongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-3454","authenticated-orcid":false,"given":"Awo Afi","family":"Kwapong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-9615","authenticated-orcid":false,"given":"Kennedy Kwami Edem","family":"Kukuia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph3010019"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5845491"},{"key":"e_1_2_13_3_2","volume-title":"Antidepressant Activity of Methanolic Extract of Amaranthus Spinosus","author":"Kumar A.","year":"2014"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1125"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278231"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08147"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08465"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.93918"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.09.023"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.5567\/pharmacologia.2012.683.692"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0043-31442006000400003"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104527"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.183226"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2015-0029"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/324063"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.09.024"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18178"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s78131"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13924"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy091"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2012.03.014"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-018-0394-4"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2020.e00609"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2015.50414"},{"key":"e_1_2_13_25_2","article-title":"Aulton-Pharmaceutics-The-Design-And-Manufacture-Of-Medicines-5th-Edition","volume":"5","author":"Aulton Kmgt M. 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