{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:40:34Z","timestamp":1791492034354,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) occurs as a result of a chronic neurodegenerative disorder that is most frequently linked to a decline in cognitive function and memory. Twenty\u2010four male rats were divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096); Group I was the negative control, Group II was the AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010positive control, and Group III and Group IV were treated with 100\u2009mg and 200\u2009mg\/kg of\n                    <jats:italic>Portulaca oleracea<\/jats:italic>\n                    methanolic extract, respectively. Aluminum chloride intoxication in Group II increased lipid peroxidation and decreased antioxidant parameters and affected interleukin\u20106 (IL\u20106), the tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), acetylcholinesterase (AChE), and amyloid beta (A\u03b2), which lead to the induction of AD through injuring brain cells of AD rats. Treating the AD rats in Group III (GIII) and Group IV (GIV) with\n                    <jats:italic>P. oleracea<\/jats:italic>\n                    ameliorated the altered parameters in the AD rats. It also increased folic acid and vitamin B12 levels.\n                    <jats:italic>P. oleracea<\/jats:italic>\n                    modulated the physiological, biochemical, and histological changes brought on by AlCl\n                    <jats:sub>3<\/jats:sub>\n                    intoxication in rats via oxidative stress and inflammatory pathways. The dose of\n                    <jats:italic>P. oleracea<\/jats:italic>\n                    in GIV successfully modified the behavioral changes brought on by AlCl\n                    <jats:sub>3<\/jats:sub>\n                    in the AD rats more than that of GIII.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/7701263","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T03:35:22Z","timestamp":1740195322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Portulaca oleracea<\/i>\n                    L. Methanolic Extract Protects the Brain of Male Rats Against Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4347-6864","authenticated-orcid":false,"given":"Haddad A.","family":"El Rabey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar M.","family":"Rezk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham A.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zienab","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mennatallah","family":"Loutfy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel I.","family":"Alalawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmene F.","family":"Alenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Sheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bakry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Stat Pearls. 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