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Wistar rats were arranged into four groups and fed one of the following four diets: standard diet (Control), 2% (w\/w) PEF\u2010supplemented standard diet (Control\u2009+\u2009PEF), HFD, and 2% (w\/w) PEF\u2010supplemented HFD (HFD\u2009+\u2009PEF). The treatment was continued for 8\u2009weeks, after which the effects of PEF on oxidative stress, fat deposition, plasma lipids, and gene expression of relevant proteins were explored. Several proteins involved in lipid metabolism and homeostasis interact with bioactive phenolic compounds, such as ellagic acid, quercetin, catechin, kaempferol, and chrysin. The presence of these compounds in the\n                    <jats:italic>P. emblica<\/jats:italic>\n                    fruit was confirmed by HPLC analysis.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments showed that HFD\u2010induced increased oxidative stress, mesenteric fat weight, and harmful plasma lipids were reduced significantly (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) due to the feeding of PEF\u2010supplemented HFD. On the other hand, HFD\u2010mediated reductions in antioxidant enzyme activity and the level of HDL cholesterol were restored in rats fed with PEF. The HFD\u2010mediated increase in the transcript levels of SREBP\u20101c, SREBP\u20102, and HMGCR reductase was significantly (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) suppressed by feeding PEF with a parallel increase in the expression of LDLR. However, the increased expression of LXR\u03b1, PPAR\u03b3, and FABP4 was not changed by PEF feeding, although these proteins strongly interacted with several compounds of PEF. This study demonstrated that a PEF\u2010supplemented diet can reduce HFD\u2010induced hyperlipidemia by modulating the expression of SREBP\u20101c, SREBP\u20102, HMG\u2010CoA reductase, and LDL receptor at the transcriptional level.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/7941857","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T10:36:06Z","timestamp":1767090966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Constituents of\n                    <i>Phyllanthus emblica<\/i>\n                    Fruit Ameliorate Hyperlipidemia Through the Modulation of SREBPs, HMG\u2010CoA Reductase, and LDL Receptor Pathway"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-5141","authenticated-orcid":false,"given":"Syed Abdul","family":"Kuddus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-5151","authenticated-orcid":false,"given":"Md. 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