{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:38:13Z","timestamp":1772987893323,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100021032","name":"Phranakhon Rajabhat University","doi-asserted-by":"publisher","award":["02.008\/2567"],"award-info":[{"award-number":["02.008\/2567"]}],"id":[{"id":"10.13039\/100021032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The hunt for alternative antidiabetic treatments that result in fewer side effects judged against established treatments is being powered by the mounting worldwide pervasiveness of diabetes mellitus. Playing a critical role in many biological processes,\n                    <jats:italic>Baccaurea ramiflora<\/jats:italic>\n                    , a long\u2010established medicinal plant commonly used throughout Southeast Asia, presents abundant health benefits. An assessment of the various ethanol extracts from\n                    <jats:italic>B. ramiflora<\/jats:italic>\n                    drawn from the leaves, stems, stem bark, peel, and flesh with seed revealed the total phenolic and flavonoid contents in addition to the levels of inhibitory activity against the enzymes \u03b1\u2010amylase and \u03b1\u2010glucosidase. In the case of total phenolic and flavonoids contents, the findings confirmed that the leaves, flesh with seed, and peel extracts were the richest source of phenolics. The leaf extract showed higher flavonoid content than others. The greatest levels of inhibitory activity against the two enzymes of interest were exhibited by the flesh with seed and peel: the respective IC\n                    <jats:sub>50<\/jats:sub>\n                    values associated with \u03b1\u2010amylase and \u03b1\u2010glucosidase were 0.50\u2009\u00b1\u20090.03 and 0.69\u2009\u00b1\u20090.01\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for flesh with seed, and 0.61\u2009\u00b1\u20090.04 and 0.59\u2009\u00b1\u20090.01\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for peel. The various extracts were all capable of inhibiting enzyme activity in a concentration\u2010dependent manner. GC\u2010MS analysis of the flesh with seed extract identified phenol, 3,5\u2010bis(1,1\u2010dimethylethyl)\u2010, dimethylsulfoxonium formylmethylide, methyl salicylate, and other compounds. Additionally, the major compounds present in the peel extract were 2,4\u2010di\u2010tert\u2010butylphenol, dimethyl sulfone, cyclooctasiloxane, hexadecamethyl, and other compounds. From these findings,\n                    <jats:italic>B. ramiflora<\/jats:italic>\n                    offers potential for use in the field of nutraceuticals and functional foods and might also find application in treating health conditions such as diabetes.\n                  <\/jats:p>","DOI":"10.1155\/sci5\/8768659","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T03:34:03Z","timestamp":1750131243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of \u03b1\u2010Amylase and \u03b1\u2010Glucosidase Using\n                    <i>Baccaurea ramiflora<\/i>"],"prefix":"10.1155","volume":"2025","author":[{"given":"Pongsathorn","family":"Klomsakul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-9365","authenticated-orcid":false,"given":"Pornchanok","family":"Chalopagorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2021"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-s081"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2012.664134"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115119"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.12.2023"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1190105"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.34297\/ajbsr.2021.11.001683"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3329\/icpj.v4i6.23288"},{"key":"e_1_2_9_9_2","first-page":"789","article-title":"Antimicrobial Activities of Seeds of Diospyros Blancoi and Baccuarea ramiflora","volume":"4","author":"Akter S.","year":"2015","journal-title":"International Journal of Advances in Pharmacy Biology and Chemistry"},{"key":"e_1_2_9_10_2","first-page":"565","article-title":"Bioresearch Communications Isolation of Bioactive Principles and Studies of Antimicrobial, Cytotoxic and Antioxidant Activities of the Stem Bark of Baccaurea ramiflora (Euphorbiaceae)","volume":"4","author":"Mandal M.","year":"2018","journal-title":"Bioresearch Communications"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2100-5"},{"key":"e_1_2_9_12_2","first-page":"266","article-title":"Hypoglycemic, Hypolipidemic and Antioxidant Effects of Leaves Methanolic Extract of Baccaurea ramiflora","volume":"4","author":"Ullah O. M.","year":"2012","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_9_13_2","first-page":"25","article-title":"Hypolipidemic Effect of Ethanolic Seeds Extract of Baccaurea ramiflora in Wister Albino Rats","volume":"3","author":"Alam Y.","year":"2019","journal-title":"International Research Journal of Pharmacy and Medical Sciences"},{"key":"e_1_2_9_14_2","first-page":"209","article-title":"Analgesic Activities of Geodorum densiflorum, Diospyros Blancoi, Baccaurea ramiflora and Trichosanthes Dioica","volume":"4","author":"Akter S.","year":"2015","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_9_15_2","first-page":"157","article-title":"Study of Anthelmintic and Insecticidal Activity of Baccaurea ramiflora Plant in Different Extracts","volume":"3","author":"Nuruddin K.","year":"2018","journal-title":"International Journal of Food Science and Nutrition"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.7897\/2230-8407.0811234"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.11648\/j.ijnfs.20170605.15"},{"key":"e_1_2_9_18_2","first-page":"197","article-title":"Phytochemical and Comparative Biological Studies of Baccaurea ramiflora (Lour) Extract","volume":"16","author":"Paul T. R.","year":"2020","journal-title":"International Journal of Biosciences"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/fbe2.12069"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42250-020-00213-9"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.10.006"},{"key":"e_1_2_9_22_2","article-title":"Evaluation of Antioxidant Activities and Tyrosinase Inhibitory Effects of Ginkgo biloba Tea Extract","volume":"16","author":"Klomsakul P.","year":"2022","journal-title":"The Scientific World Journal"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v12i5.9"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2016.08.007"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.10.014"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ecb2023-14079"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1388-1"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0820-3"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26216431"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474x.106069"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.4103\/1995-7645.237189"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.09.122"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0204442B"},{"key":"e_1_2_9_34_2","first-page":"197","article-title":"Antioxidant Potential and Content of Phenolic Com-Pounds in Ethanolic Extracts of Selected Parts of Andrographis paniculata","volume":"4","author":"Rafat A.","year":"2010","journal-title":"Journal of Medicinal Plants Research"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-021-00943-8"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/483958"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.9.2103"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods10010137"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040280"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7296859"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.25077\/jsfk.7.1.60-66.2020"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2811"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.18433\/j35s3k"},{"key":"e_1_2_9_44_2","first-page":"128","article-title":"In Vitro Studies on Alpha Amylase and Alpha Glucosidase Inhibitory Activities of Selected Plant Extracts","volume":"3","author":"Nair S. S.","year":"2013","journal-title":"European Journal of Experimental Biology"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2482-z"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.127333"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0039"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.01.029"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00468-021-02191-y"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-6-201003160-00004"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12010035"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-021-01984-z"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2017.12.031"}],"container-title":["Scientifica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/sci5\/8768659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/sci5\/8768659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/sci5\/8768659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:10:16Z","timestamp":1772968216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/sci5\/8768659"}},"subtitle":[],"editor":[{"given":"Simone","family":"Carradori","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/sci5\/8768659"],"URL":"https:\/\/doi.org\/10.1155\/sci5\/8768659","archive":["Portico"],"relation":{},"ISSN":["2090-908X","2090-908X"],"issn-type":[{"value":"2090-908X","type":"print"},{"value":"2090-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8768659"}}