{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:08:22Z","timestamp":1785514102183,"version":"3.56.0"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":211,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560932"],"award-info":[{"award-number":["82560932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stroke Research and Treatment"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease associated with high morbidity and disability rates. It is characterized by neurological damage caused by the interruption of cerebral blood flow, often accompanied by sequelae such as motor dysfunction and cognitive decline, which seriously affect the quality of life of patients. Despite continuous advancements in treatment methods, challenges persist, such as time window constraints, limited efficacy, and potential adverse reactions. Therefore, finding more proactive and effective treatment approaches has become an urgent problem to be solved. The mechanism of action of terpenoids is not a simple single\u2010target inhibition. Essentially, it lies in the systematic remodeling of the postischemic neural microenvironment. The pathophysiological process of CIS involves complex cascades, including energy failure, excitotoxicity, oxidative stress, neuroinflammation, disruption of the blood\u2013brain barrier, multiple cell death pathways, mitochondrial dysfunction, and impairment of nerve repair. Terpenoids can intervene in ischemic stroke through a dual\u2010mechanism approach of direct neuroprotection and indirect microenvironment regulation by targeting key nodes within the abovementioned pathological network, ultimately achieving the protection and restoration of neural function. The aim of this review was to deepen the understanding of the therapeutic value of terpenoids in stroke; from an integrated perspective, it revealed the scientific essence of the multitarget synergistic effects of natural products, thereby providing a theoretical cornerstone and an innovative direction for the development of next\u2010generation drugs for treating stroke.<\/jats:p>","DOI":"10.1155\/srat\/4347247","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:28:51Z","timestamp":1785511731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress on the Multitarget Mechanisms of Terpenoids in the Treatment of Ischemic Stroke"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9206-0904","authenticated-orcid":false,"given":"Jiao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-2795","authenticated-orcid":false,"given":"Zhifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8580-3472","authenticated-orcid":false,"given":"Ting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5524-3435","authenticated-orcid":false,"given":"Shiyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7683-0113","authenticated-orcid":false,"given":"Pengfen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0687-5433","authenticated-orcid":false,"given":"Yuxin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4379-721X","authenticated-orcid":false,"given":"Daman","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0651-9917","authenticated-orcid":false,"given":"Shuangfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5858-5566","authenticated-orcid":false,"given":"Junfeng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-3975","authenticated-orcid":false,"given":"Yujiang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-2914","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873231219416"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9060529"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01064-1"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113125"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103622"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00954-y"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03459-9"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155362"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1461279"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01468-7"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.030"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10921"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00737-z"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2023.04.007"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.666790"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031197"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.69892"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110426"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202211_30391"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154112"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.023"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.5019"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106498"},{"key":"e_1_2_14_25_2","first-page":"911","article-title":"Triptolide Promotes Neuronal Plasticity in Cerebral Ischemia-Reperfusion Injury by Regulating the cAMP\/PKA\/BDNF Signaling Pathway","volume":"41","author":"Mu B. T.","year":"2024","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8796103"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106240"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117006"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-019-0125-y"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1452174"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.792136"},{"key":"e_1_2_14_32_2","first-page":"6219","article-title":"Ginsenoside Rb1 Alleviates Cerebral Ischemic Injury in Mice by Regulating Microglial Polarization","volume":"29","author":"Liu R. J.","year":"2025","journal-title":"Chinese Journal of Tissue Engineering Research"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8235"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102363"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03634.x"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8257"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/md19040201"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.2024.J103"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/md20040267"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13164"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77399-y"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118616"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000792"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-23-1487"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124874"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108312"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/gels9070550"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00002G"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.920435"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00063F"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.1c00428"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0953-6738"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2024.109120"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001803"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.941094"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2023.133065"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172418"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57774-x"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5716"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1531278"},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02534.x"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1828"},{"key":"e_1_2_14_63_2","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_703_2024"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1081347"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.01.017"},{"key":"e_1_2_14_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03292-4"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO04534C"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201024666221130163116"},{"key":"e_1_2_14_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061764"},{"key":"e_1_2_14_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17040397"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2024.13707"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2023.101826"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117100"},{"key":"e_1_2_14_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.009"},{"key":"e_1_2_14_75_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S122859"},{"key":"e_1_2_14_76_2","first-page":"681","article-title":"Design and Research Progress of Mitochondrial - Targeted Nanodrug Delivery Systems","volume":"57","author":"Baoxin Z.","year":"2022","journal-title":"Acta Pharmaceutica Sinica"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00895-4"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108124"},{"key":"e_1_2_14_79_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3NP00005B"},{"key":"e_1_2_14_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-021-11312-z"},{"key":"e_1_2_14_81_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-024-02512-z"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.02.008"}],"container-title":["Stroke Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/srat\/4347247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/srat\/4347247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/srat\/4347247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:28:54Z","timestamp":1785511734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/srat\/4347247"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/srat\/4347247"],"URL":"https:\/\/doi.org\/10.1155\/srat\/4347247","archive":["Portico"],"relation":{},"ISSN":["2090-8105","2042-0056"],"issn-type":[{"value":"2090-8105","type":"print"},{"value":"2042-0056","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4347247"}}