{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:50:32Z","timestamp":1782395432362,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":175,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stroke Research and Treatment"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Use of sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) in adults with Type 2 diabetes (AwT2D) has recently been associated with decreased stroke risk. In this study, we investigate the impact of SGLT2i on stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a cohort study using an electronic health record (EHR) representing 66 million patients to examine whether AwT2D have a lower incidence of stroke and\/or transient ischemic attack (TIA) if treated with SGLT2i. All analyses were completed utilizing high\u2010dimensional propensity score matching to control for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AwT2D treated with SGLT2i compared to other antidiabetic medications, assessed after 1 year, starting 2 weeks after the date of prescription of SGLT2i or other antidiabetic drug, had a significantly lower incidence of any stroke (Odds Ratio (OR): 0.84 with 95% Confidence Interval (CI) 0.79\u20130.91,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), hemorrhagic stroke (OR: 0.72 with 95% CI 0.59\u20130.88,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), ischemic stroke (OR: 0.86 with 95% CI 0.77\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), and TIA (OR: 0.87 with 95% CI 0.80\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among AwT2D, those treated with SGLT2i had lower incidence of stroke and TIA compared with adults treated with other antidiabetic medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/srat\/6411721","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:15:27Z","timestamp":1782393327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Evidence Assessment of the Risk of Nonfatal Stroke in Patients Prescribed SGLT2 Inhibitors"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3054-3207","authenticated-orcid":false,"given":"Alessandra T.","family":"Ayers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3067-1004","authenticated-orcid":false,"given":"Cindy N.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-804X","authenticated-orcid":false,"given":"Umesh","family":"Masharani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-1559","authenticated-orcid":false,"given":"William C.","family":"Pike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5410-3669","authenticated-orcid":false,"given":"Honor","family":"Magon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-0256","authenticated-orcid":false,"given":"Michael L.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-8569","authenticated-orcid":false,"given":"Saurabh","family":"Gombar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4211-4934","authenticated-orcid":false,"given":"Agatha F.","family":"Scheideman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9550-9965","authenticated-orcid":false,"given":"Mandy M.","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-6862","authenticated-orcid":false,"given":"David C.","family":"Klonoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14070665"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.6139"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069568"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020279"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107730"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/10600280251317495"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-0772"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105836"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2022.0421"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2024.0079"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94945-4"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.15036"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.01.015"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a663cc"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv108"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer.15.53"},{"key":"e_1_2_14_17_2","volume-title":"The Elements of Statistical Learning: Data Mining, Inference, and Prediction","author":"Hastie T.","year":"2008"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000366"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e213"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0007022020"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac018"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032463"}],"container-title":["Stroke Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/srat\/6411721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/srat\/6411721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/srat\/6411721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:15:28Z","timestamp":1782393328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/srat\/6411721"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/srat\/6411721"],"URL":"https:\/\/doi.org\/10.1155\/srat\/6411721","archive":["Portico"],"relation":{},"ISSN":["2090-8105","2042-0056"],"issn-type":[{"value":"2090-8105","type":"print"},{"value":"2042-0056","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6411721"}}