{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:03:31Z","timestamp":1789729411539,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20238"],"award-info":[{"award-number":["U23A20238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230104"],"award-info":[{"award-number":["32230104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Nanozymes offer promising alternatives to natural enzymes due to enhanced stability, tunable activity, and cost efficiency, demonstrating therapeutic potential against tumors, infections, and inflammatory disorders.\n                    <jats:italic>Trichinella spiralis<\/jats:italic>\n                    is an important pathogen, which globally prevalent foodborne zoonotic parasite. Chemical drug is commonly used to kill\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    , but there are risks of chemical abuse and drug resistance. Here, we engineered MPG(Fe), a cascade nanozyme formed by covalently conjugating glucose oxidase (GOx) to a metal\u2010organic framework\u2010Fe nanozyme (MOF\u2010525[Fe]) nanozyme via the bifunctional PEG linker. In vitro, MPG(Fe) depleted glucose through GOx\u2010catalyzed conversion to gluconic acid and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , while MOF\u2010525(Fe) subsequently transformed H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into cytotoxic hydroxyl radicals (\u2022OH). This dual\u2010action mechanism dose\u2010dependently killed intestinal\u2010stage adult worms and newborn larvae (NBL) of\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    . In a BALB\/c mouse model of intestinal\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infection, high\u2010dose MPG(Fe) reduced the survival of intestinal adult worms to 3.53% of the control value through the synergistic actions of glucose deprivation and hydroxyl radical (\u2022OH)\u2010mediated oxidative damage. Critically, MPG(Fe) exhibited no tissue toxicity in uninfected mice. Our findings establish enzyme\u2010mimetic nanozymes as a novel therapeutic platform against zoonotic helminthiases.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/3527187","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:22:32Z","timestamp":1789726952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Natural Enzyme GOx\u2010MOF Cascade Complex Killing Zoonotic Parasite\n                    <i>Trichinella spiralis<\/i>\n                    by Energy Utilization Limitation and Generated Free Radicals"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-6648","authenticated-orcid":false,"given":"Chuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-0876","authenticated-orcid":false,"given":"Xiaolei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2260-5242","authenticated-orcid":false,"given":"Zipei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4081-0387","authenticated-orcid":false,"given":"Zhili","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5604-4253","authenticated-orcid":false,"given":"Xu","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4400-6679","authenticated-orcid":false,"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-1105","authenticated-orcid":false,"given":"Mingyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-2117","authenticated-orcid":false,"given":"Zhengqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3103-3097","authenticated-orcid":false,"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_13_1_2","first-page":"105","article-title":"Ultrastructural Observations on the In Vitro Interaction Between Rat Eosinophils and Some Parasitic Helminths (Schistosoma mansoni, Trichinella spiralis and Nippostrongylus brasiliensis)","volume":"30","author":"McLaren D. 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