{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:18:45Z","timestamp":1787894325577,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":238,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The aim of this retrospective cohort study was to evaluate clinical outcomes of penicillin\u2010based therapies (ampicillin, ampicillin\/sulbactam, or piperacillin\/tazobactam) compared with alternative therapies (glycopeptides, linezolid, or daptomycin) in patients with vancomycin\u2010susceptible enterococcal bloodstream infections (BSIs). Adult patients with a positive blood culture (BC) for a vancomycin\u2010susceptible\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    species were screened from January 2017 to December 2018. Patients who received adequate antibiotic therapy for at least 48\u2009h were enrolled. The primary outcome, 30\u2010day mortality, was compared between patients receiving penicillin\u2010based and those receiving alternative therapies using the Fisher exact test. Secondary outcomes included 90\u2010day mortality, relapse BSI, length of hospital stay (LOS), and potential antibiotic\u2010related adverse events. To identify independent predictors of 30\u2010day mortality, multivariable logistic regression analysis was weighted for ampicillin susceptibility using propensity scores. Of the 150 patients screened, 127 (84.6%) were included in the final analysis. Among them, 36 (28.3%) developed a septic shock. Aminopenicillin\u2010susceptible\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    species (mainly\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    ) accounted for 59.1% of bacteremia cases. Sixty\u2010seven (52.1%) patients received a penicillin\u2010based regimen (monotherapy\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200948, combination\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919), and 60 (47.2%) patients received an alternative regimen. Patients receiving penicillin\u2010based therapy exhibited a lower 30\u2010day mortality rate of 13.4% compared to 40% (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001) in those receiving alternative treatments. The 90\u2010day mortality rates were reduced (13.4% versus 41.7%), and LOS was shorter (median 21 versus 35 days) for patients with penicillin\u2010based therapy. There was no significant difference in relapse BSI or potential adverse events between the groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &gt; 0.05). However, in the multivariable weighted regression model, only septic shock (aOR with 95% CI: 23.53 [1.66; 334.54]) was identified as an independent positive predictor of 30\u2010day mortality. In conclusion, penicillin\u2010based therapy was still an effective and safe treatment but was not associated with an improved survival in a weighted analysis of patients with enterococcal BSI.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/3822590","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:43:43Z","timestamp":1787892223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Penicillin\u2010Based Therapy Compared to Alternative Enterococcal Treatment in Patients With Vancomycin\u2010Susceptible Enterococcal Bloodstream Infections: A Monocentric Cohort Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5541-3804","authenticated-orcid":false,"given":"Thalia","family":"Landrock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-4702","authenticated-orcid":false,"given":"Lisa","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-5366","authenticated-orcid":false,"given":"Stefan","family":"Gl\u00f6ckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-6131","authenticated-orcid":false,"given":"Stefan","family":"Hagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-2753","authenticated-orcid":false,"given":"Mathias W.","family":"Pletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-2839","authenticated-orcid":false,"given":"Christina","family":"Bahrs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.026385-0"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.45.2001628"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.10.029"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.02.012"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-024-04917-5"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00997-6"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-022-02926-w"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.33321\/cdi.2024.48.56"},{"key":"e_1_2_13_10_2","volume-title":"Antimicrobial Resistance in the EU\/EEA (EARS-Net) \u2013 Annual Epidemiological Report 2023","author":"European Centre for Disease and Infection Control","year":"2024"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.08.023"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlad063"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.14041"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-023-02074-z"},{"key":"e_1_2_13_15_2","volume-title":"Medical Microbiology - 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