{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:54:41Z","timestamp":1781693681072,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302881"],"award-info":[{"award-number":["32302881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["FN2600640636"],"award-info":[{"award-number":["FN2600640636"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB23075145"],"award-info":[{"award-number":["AB23075145"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012421","name":"Agricultural Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["CAAS-ASTIP-2026-SHVRI"],"award-info":[{"award-number":["CAAS-ASTIP-2026-SHVRI"]}],"id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Multidrug\u2010resistant (MDR) bacteria have reduced the effectiveness of antimicrobial agents and limited available treatment options in both human and animal settings. Antimicrobial resistance (AMR) in animal\u2010derived\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ) has become increasingly common, with many isolates showing resistance to multiple classes of antimicrobials. However, compared with other animal sources, resistance characteristics of\n                    <jats:italic>E. coli<\/jats:italic>\n                    from mink remain less well understood, particularly in terms of genomic features. In this study, we identified a MDR\n                    <jats:italic>E. coli<\/jats:italic>\n                    strain, EC0D1, isolated from the lung tissue of a farmed mink that succumbed to hemorrhagic pneumonia (HP) in China. Antimicrobial susceptibility testing indicated that EC0D1 exhibited resistance to \u03b2\u2010lactams, fluoroquinolones, aminoglycosides, tetracyclines, and polymyxins but was sensitive to carbapenems and tigecycline. Whole genome sequencing showed that EC0D1 contains a single chromosome and eight plasmids. Among these, plasmid pEC0D1\u20103 coharbored\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX-M\u221255<\/jats:sub>\n                    and\n                    <jats:italic>mcr-1.1<\/jats:italic>\n                    , while pEC0D1\u20102 carried\n                    <jats:italic>tet<\/jats:italic>\n                    (A) and\n                    <jats:italic>floR<\/jats:italic>\n                    , together explaining the observed MDR phenotype. Phylogenetic analysis classified EC0D1 as sequence type ST457 and demonstrated a close genetic relationship with several human clinical isolates. Comparative genomic analysis further revealed that plasmids pEC0D1\u20102 and pEC0D1\u20103 shared high sequence similarity with plasmids previously identified in avian\u2010derived\n                    <jats:italic>E. coli<\/jats:italic>\n                    and human\u2010derived\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    isolates. Conjugation assays confirmed that plasmids carrying\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX-M\u221255<\/jats:sub>\n                    ,\n                    <jats:italic>mcr-1.1<\/jats:italic>\n                    ,\n                    <jats:italic>tet<\/jats:italic>\n                    (A), and\n                    <jats:italic>floR<\/jats:italic>\n                    were transferable to different bacterial recipients. The emergence of transferable resistance determinants in mink\u2010associated\n                    <jats:italic>E. coli<\/jats:italic>\n                    suggests a potential role in the transmission of resistance genes between human and animal hosts.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/4811804","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:21:26Z","timestamp":1781691686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of Transferable Plasmid Coharboring\n                    <i>mcr-1.1<\/i>\n                    and\n                    <i>bla<\/i>\n                    <sub>CTX-M\u221255<\/sub>\n                    Genes in Multidrug\u2010Resistant\n                    <i>Escherichia coli<\/i>\n                    From Mink"],"prefix":"10.1155","volume":"2026","author":[{"given":"Zizhu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-949X","authenticated-orcid":false,"given":"Xue","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-9640","authenticated-orcid":false,"given":"Haihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0170-3309","authenticated-orcid":false,"given":"Shaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.glmedi.2024.100081"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani10122239"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029917000206"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252313000170"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7010089"},{"key":"e_1_2_13_6_2","first-page":"256","article-title":"Molecular 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Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tbed\/4811804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/tbed\/4811804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tbed\/4811804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:21:27Z","timestamp":1781691687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/tbed\/4811804"}},"subtitle":[],"editor":[{"given":"Zhong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/tbed\/4811804"],"URL":"https:\/\/doi.org\/10.1155\/tbed\/4811804","archive":["Portico"],"relation":{},"ISSN":["1865-1674","1865-1682"],"issn-type":[{"value":"1865-1674","type":"print"},{"value":"1865-1682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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