{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:25:36Z","timestamp":1775060736068,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016230","name":"Steven and Alexandra Cohen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010304","name":"Pershing Square Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Controlling populations of\n                    <jats:italic>Ixodes<\/jats:italic>\n                    ticks has emerged as a core strategy for reducing human exposure to tick\u2010borne infections. Several means of reducing the size of the tick population using chemical and biological acaricides show promise in field trials and are frequently used commercially in North America and Europe. The Tick Project (TTP) assessed whether the use of two commercially available methods of reducing the abundance of host\u2010seeking blacklegged ticks (\n                    <jats:italic>Ixodes scapularis<\/jats:italic>\n                    ) reduced encounters with ticks and reported cases of tick\u2010borne disease in humans and their outdoor pets. Residential neighborhoods were the units of replication. Here, we synthesize the results of this large\u2010scale, long\u2010term ecological and epidemiological study and integrate them with comparable literature to assess: (1) the peridomestic risk factors linked to tick encounters and cases of tick\u2010borne disease; (2) the spatial scale of these risk and response factors; (3) discordance between ecological consequences of tick control (strongly reduced tick abundance) and weak or undetectable epidemiological responses; (4) possible causes of the failure of tick control to reduce disease incidence; and (5) future approaches to preventing tick\u2010borne disease with environmentally\u2010 and behaviorally\u2010based interventions. We conclude that the low efficacy of tick control in reducing cases of tick\u2010borne disease observed to date could be improved with greater attention to human behaviors that affect exposure risk.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/4940832","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:32:57Z","timestamp":1769077977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ecological and Epidemiological Consequences of Tick\u2010Control Interventions in Residential Neighborhoods: A Synthesis of The Tick Project"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-9301","authenticated-orcid":false,"given":"Richard S.","family":"Ostfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-695X","authenticated-orcid":false,"given":"Felicia","family":"Keesing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/15303667251364142"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0841"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6717e1"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6622a1"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2022.0068"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.12.006"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2744-5"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.666554"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168613"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.02.020"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1183344"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2022.101925"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0374"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2015.03.017"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2019.07.008"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12984"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2015.12.003"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjz215"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12020172"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjaa079"},{"key":"e_1_2_10_21_2","first-page":"403","article-title":"Evaluation of Doxycycline-Laden Oral Bait and Topical Fipronil Delivered in a Single Bait Box to Control Ixodes scapularis (Acari: Ixodidae) and Reduce Borrelia burgdorferi and Anaplasma phagocytophilum Infection in Small Mammal Reservoirs and Host-Seeki","volume":"54","author":"Dolan M. 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