{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:12:54Z","timestamp":1791544374731,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["202206010192"],"award-info":[{"award-number":["202206010192"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017687","name":"Guangdong Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["XTXM202202"],"award-info":[{"award-number":["XTXM202202"]}],"id":[{"id":"10.13039\/501100017687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    As the only member of the genus\n                    <jats:italic>Senecavirus<\/jats:italic>\n                    within the family\n                    <jats:italic>Picornaviridae<\/jats:italic>\n                    , Senecavirus A (SVA) has posed an enormous challenge for the pig industry worldwide. In our previous study, a SVA strain was isolated from a buffalo with mouth ulcers. To systematically assess its pathogenicity, this study compared the outcome of piglets and buffaloes artificially infected by the different viral dose of the buffalo\u2010origin SVA strain (SVA\/GD\/China\/2018). These results indicated that vesicular diseases can occur in infected piglets and buffaloes. Severe clinical symptoms were observed in the piglets and buffaloes with the inoculation of 10\n                    <jats:sup>5.0<\/jats:sup>\n                    50% tissue culture infective dose (TCID\n                    <jats:sub>50<\/jats:sub>\n                    \/mL). The SVA antigen expression was also detected in the lung tissue, chin blister lesion tissue, nasolabial tissue of the piglets, and the upper lip blister tissue of the buffaloes. This study demonstrated that the buffalo\u2010origin SVA strain was pathogenic to piglets and buffaloes, revealing the possibility of cross\u2010species transmission of SVA between pigs and buffaloes. In the future, it is necessary to strengthen the surveillance of SVA in cattle herds.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/6222217","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:05:00Z","timestamp":1756811100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pathogenicity of the First Buffalo\u2010origin Senecavirus A in Conventional Piglets and 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