{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:03:13Z","timestamp":1779696193906,"version":"3.53.1"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Transmitted by tick vectors,\n                    <jats:italic>Ehrlichia canis<\/jats:italic>\n                    (\n                    <jats:italic>E. canis<\/jats:italic>\n                    ) is a Gram\u2010negative, obligate intracellular bacterium of zoonotic concern that infects both canine and human hosts. Its pathogenesis centers on the targeting of mononuclear phagocytes, where it establishes an intracellular niche by suppressing phagolysosomal fusion and evading immune detection, thereby facilitating its replication.\n                    <jats:italic>E. canis<\/jats:italic>\n                    infection also compromises mitochondrial integrity, notably by disrupting the mitochondrial membrane potential (MMP, or \u0394\u03a8m), which triggers cellular stress and perturbs critical processes such as autophagy and apoptosis. The energy sensor AMP\u2010activated protein kinase (AMPK), a central regulator of mitochondrial metabolism and cellular homeostasis, plays a critical role in mediating stress\u2010responsive pathways, including those governing autophagy and apoptosis. This review examines the interplay between\n                    <jats:italic>E. canis<\/jats:italic>\n                    and host mitochondria, with a focus on AMPK\u2010directed regulation of autophagy and apoptosis during infection. We summarize current knowledge on the mechanisms of mitochondrial dysfunction and AMPK signaling activation, and discuss the dual roles of autophagy and apoptosis in the pathogen\u2019s life cycle and disease progression. By delineating these molecular mechanisms, this review aims to advance the understanding of\n                    <jats:italic>E. canis<\/jats:italic>\n                    pathogenesis and inform future strategies for the control of canine monocytic ehrlichiosis (CME).\n                  <\/jats:p>","DOI":"10.1155\/tbed\/8787897","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:15:26Z","timestamp":1779693326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Dysfunction in\n                    <i>Ehrlichia canis<\/i>\n                    Infection"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-4749","authenticated-orcid":false,"given":"Xishuai","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2010-3216","authenticated-orcid":false,"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8136-4938","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8577-6455","authenticated-orcid":false,"given":"Yunying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8514-7863","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3835-3628","authenticated-orcid":false,"given":"Xiaohui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6239-1872","authenticated-orcid":false,"given":"Gengsheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0221-1468","authenticated-orcid":false,"given":"Naineng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0752-3889","authenticated-orcid":false,"given":"Shuo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-1299","authenticated-orcid":false,"given":"Siyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-8616","authenticated-orcid":false,"given":"Shucheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7141-4555","authenticated-orcid":false,"given":"Jameel Ahmed","family":"Buzdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-8180","authenticated-orcid":false,"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-8363","authenticated-orcid":false,"given":"Zongping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens13121119","article-title":"Serosurvey of Rickettsia Spp. and Ehrlichia canis in Dogs From Shelters in Sicily (Southern Italy)","volume":"13","author":"Di Bella S.","year":"2024","journal-title":"Pathogens"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601253340410"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012377"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.12.2838-2842.1991"},{"key":"e_1_2_14_5_2","article-title":"Worldwide Meta-Analysis on Anaplasma phagocytophilum Infections in Animal Reservoirs: Prevalence, Distribution and Reservoir Diversity","volume":"38","author":"Karshima S. 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